- Individualized dosing of oral propranolol for treatment of infantile hemangioma: a prospective study. [Journal Article]
- PAPan Afr Med J 2019; 32:155
- CONCLUSIONS: Propranolol in a lower dose of 1-1.5 mg/kg/day is safe and efficacious in the treatment of infantile hemangioma and the lesions which do not show initial response to the lower dose are unlikely to respond to the higher dose of 3-4 mg/kg/day.
- Infantile hemangioma: an update in the topical and systemic treatments. [Journal Article]
- BMBol Med Hosp Infant Mex 2019; 76(4):167-175
- Infantile hemagiomas (IH) are the most common soft tissue tumors in infancy. They are characterized by significant growth during the first months of life, followed by slow spontaneous involution over…
Infantile hemagiomas (IH) are the most common soft tissue tumors in infancy. They are characterized by significant growth during the first months of life, followed by slow spontaneous involution over the ensuring years. The process of involution takes several years, but usually the regression of most of the tumors ends at 4 years of age. Unfortunately, some of the IH develop complications, resulting in functional impairment, pain and disfigurement. The decision to start treatment and the choice of the best therapeutic option (topic or systemic) should be individualized depending on several factors: the size of the lesion, the location, the presence of complications such as ulceration, the risk of scarring or disfigurement, the age of the patient, the rate of growth or regression at the time of diagnosis, the risks and benefits of the treatment, the availability of the medication, the costs, and the experience of the attending physician.
- Cutaneous mastocytosis and infantile hemangioma. Only a coincidence? [Journal Article]
- GIG Ital Dermatol Venereol 2019 Jul 12
- A Life Threatening Subglottic and Mediastinal Hemangioma in an Infant. [Journal Article]
- JCJ Craniofac Surg 2019; 30(5):e402-e404
- Subglottic and mediastinal hemangioma are rare benign vascular tumors of childhood. They cause potentially life threatening condition which requires intervention. Several therapeutic options have bee…
Subglottic and mediastinal hemangioma are rare benign vascular tumors of childhood. They cause potentially life threatening condition which requires intervention. Several therapeutic options have been described in the literature with varying degrees of success and complications. We report a case of a stridulous 2-month old female infant with mediastinal and subglottic hemangioma. The child was treated with propranolol without the need for tracheostomy or any other surgical intervention, and with no reported side effects. Propranolol is an effective, non-invasive treatment for life threatening infantile hemangiomas compressing the airway, should be used as a firstline treatment for subglottic hemangiomas when intervention is required.
- Preliminary Report of a True NasoMaxillary Infantile Fibrosarcoma: Single-Modality Management and 2-Year Follow-Up. [Case Reports]
- AMAnn Maxillofac Surg 2019 Jan-Jun; 9(1):208-210
- Infantile fibrosarcoma (IFS) is a malignant tumor, commonly presenting in long bones and seldom encountered after 2 years of age. It is extremely rare in the faciomaxillary region. The condition is o…
Infantile fibrosarcoma (IFS) is a malignant tumor, commonly presenting in long bones and seldom encountered after 2 years of age. It is extremely rare in the faciomaxillary region. The condition is often mistaken for teratomas, and histopathology/immunohistochemistry is confirmatory. Treatment involves surgical resection as primary modality. Prognosis is much better compared to the adult variant with even scope for spontaneous regression following "conservative" resection. We present a case of IFS of the nasomaxillary complex in a 3-month-old female child. We managed our case with surgical resection, and the patient has remained disease free for over 2 years.
- Surgical Treatment of Infantile Hemangioma Involuted With Fatty Degeneration. [Journal Article]
- OPOphthalmic Plast Reconstr Surg 2019 Jul/Aug; 35(4):409-411
- Clivus Hemangioma in a pediatric patient: Case report. [Journal Article]
- WNWorld Neurosurg 2019 Jul 04
- CONCLUSIONS: Surgical safety margins are highly important to prevent recurrence in this type of bone tumors. Skull base hemangiomas are a big challenge when you want to achieve these safety margins. We believe that a combined treatment of surgery and radiotherapy should be considered as the main treatment.
- Safety of intralesional injection of lauromacrogol combined with triamcinolone for infantile hemangiomas. [Journal Article]
- JDJ Dermatol 2019 Jul 04
- The efficacy of lauromacrogol injection therapy and intralesional triamcinolone for infantile hemangiomas (IH) has been well documented recently, but with an increase in serious or rare adverse react…
The efficacy of lauromacrogol injection therapy and intralesional triamcinolone for infantile hemangiomas (IH) has been well documented recently, but with an increase in serious or rare adverse reactions. The aim of this study is to investigate the safety concerns regarding intralesional injection of lauromacrogol combined with triamcinolone for IH and to study its effect on infant growth and development. A total of 1039 IH patients who were subjected to intralesional injection of lauromacrogol combined with triamcinolone in the Plastic Surgery Department of Shandong Provincial Hospital between 1 January 2015 and 31 May 2018 were enrolled in this study. When the dose of lauromacrogol and triamcinolone was less than 3.5 and 2.0 mg/kg respectively, no serious side-effects were observed. The adverse event rate reported was 7.7%. Among the 405 patients not subjected to propranolol before the last injection, the study included three modes of treatment response: regression (82.7%), stabilization (13.8%) and failure (3.5%). By comparing height and weight to the reference standards and also by comparisons between the same-sex groups, our results confirmed that there was no significant effect on children's height and weight, regardless of whether the injection therapy was combined with oral propranolol at the appropriate dose and with more than 4-week intervals. Intralesional injection of lauromacrogol combined with triamcinolone in the treatment of IH was highly safe and effective.
- Deep coma in a child treated with propranolol for infantile hemangioma. [Journal Article]
- BPedBMC Pediatr 2019 Jul 02; 19(1):216
- CONCLUSIONS: Early identification of these adverse effects can be of great importance for patient management and prognosis. It must certainly be noted that not just early identification among doctors, but education for parents is crucial.
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- Oral Propranolol in Infantile Hemangiomas: Analysis of Factors that Affect the Outcome. [Journal Article]
- JIJ Indian Assoc Pediatr Surg 2019 Jul-Sep; 24(3):170-175
- CONCLUSIONS: Oral propranolol at 2-3 mg/kg/day dosing has shown to be effective and safe for IHs in pediatric age group. Intervention in the early proliferative phase, with especially, the cephalic lesions result in better resolution rates with shorter duration of overall treatment.