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26,376 results
  • Fibrocytes in Chronic Periaortitis. [Journal Article]
  • ARArthritis Rheumatol 2019 Jun 24
  • Nicastro M, Vescovini R, … Vaglio A
  • CONCLUSIONS: Fibrocytes are enriched in the peripheral blood of CP patients and infiltrate target lesions; their accumulation in the pathologic tissue might be driven by CXCL12, and Th2-skewed immune responses are likely to facilitate their differentiation. This article is protected by copyright. All rights reserved.
  • [Erythroderma revealing IPEX syndrome]. [Journal Article]
  • ADAnn Dermatol Venereol 2019 Jun 21
  • Bachelerie M, Merlin E, … D'Incan M
  • CONCLUSIONS: IPEX syndrome is characterized by early secretory enteropathy with profuse diarrhea, dermatitis and diabetes mellitus. Onset usually occurs within the first weeks or months of life, and the natural course of the disease is often lethal. Cutaneous manifestations appear to be mostly eczematiform, psoriasiform or ichthyosiform. These may be the first sign of the disease and a common inflammatory skin disorder may be wrongly diagnosed. The severity of the lesions and their limited response to topical steroids should alert the clinician.The early onset of severe cutaneous manifestations with persistent lesions and poor response to topical steroids should lead to an early skin biopsy. If histopathological changes show a cytotoxic lymphocytic infiltrate with keratinocyte necrosis, a diagnosis of primary immunodeficiency must be considered enabling rapid intitation of specific management.
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