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869,294 results
  • Reinvestigation of Herniaria glabra L. saponins and their biological activity. [Journal Article]
    Phytochemistry 2019; 169:112162Kozachok S, Pecio Ł, … Oleszek W
  • Twelve undescribed triterpenoid pentacyclic glycosides, medicagenic acid (3-O-β-D-glucuronopyranosyl-28-O-{[β-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)]-[α-L-rhamnopyranosyl-(1 → 3)]-4-O-acetyl-β-D-fucopyranosyl-(1→)}-2β,3β-dihydroxyolean-12-ene-23,28-dioic acid, 3-O-β-D-glucuronopyranosyl-28-O-{[α-L-rhamnopyranosyl-(1 → 2)]-[β-D-apiofuranosyl-(1 → 3)]-4-O-acetyl-β-D-fucopyranosyl-(1→)…
  • The endocannabinoid system: Novel targets for treating cancer induced bone pain. [Review]
    Biomed Pharmacother 2019; 120:109504Sun J, Zhou YQ, … Ye DW
  • Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and underlying mechanisms of CIBP remain unclear. Recently, emerging body of evidence suggested the endocannabinoid system (ECS) may play essential roles in CIBP. Here, we summarized the current understanding of the antinociceptive mechanisms of endocannabinoids in CIBP and discussed the beneficial effects of endo…
  • Antibacterial, antifungal and antioxidant activity of total polyphenols of Withania frutescens.L. [Review]
    Bioorg Chem 2019; 93:103337El Moussaoui A, Jawhari FZ, … Bari A
  • Our objective in this work is evaluated the antibacterial, antifungal and antioxidant activity of the phytochymic compounds of the roots and leaves of a species Withania frutescens. In the first part, the phenolic compound is determinate by the Folin-Ciocalteau reaction, the richness of the roots in polyphenols (53.33 ± 1.20 mg EGA/g Extract) is six times higher than that of the leaves. The antio…
  • Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors. [Journal Article]
    Bioorg Chem 2019; 93:103349Abdel-Maksoud MS, Ammar UM, … Oh CH
  • In the present work, a novel series of B-RAF kinase inhibitors having imidazo[2,1-b]oxazole scaffold was designed and synthesized based on the structures of the well-known B-RAF inhibitors. The twenty two final compounds were tested over A375 and SKMEL28 cell lines to determine the primary cytotoxic activity of these compounds, and their activities were compared with that of sorafenib as a standa…
  • Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor. [Journal Article]
    Eur J Med Chem 2019; 184:111755Soumyanarayanan U, Ramanujulu PM, … Dymock BW
  • Herein, we report the discovery of a dual histone deacetylase inhibitor displaying a unique HDAC3/6 selectivity profile. An initial strategy to merge two epigenetic pharmacophores resulted in the discovery of potent HDAC6 inhibitors with selectivity over HDAC1. Screening in an HDAC panel revealed additional low nanomolar inhibition only against HDAC3. Low micromolar antiproliferative activities a…
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