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634,433 results
  • Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion. [Journal Article]
    Cancer Lett 2019Jiang Y, Zhan H
  • Immune checkpoint blockage has been considered a breakthrough in cancer treatment, achieving encouraging anti-tumor effects in some advanced solid malignancies. However, low response rate and therapeutic resistance represent significant challenges in this field. In addition to its typical role in embryonic development and tissue fibrosis, epithelial-mesenchymal transition (EMT) plays a pivotal ro…
  • The combination of BET and PARP inhibitors is synergistic in models of cholangiocarcinoma. [Journal Article]
    Cancer Lett 2019Fehling SC, Miller AL, … Yoon KJ
  • Our previous finding that the BET inhibitor (BETi) JQ1 increases levels of the DNA damage marker γH2AX suggested that JQ1 might enhance the sensitivity of tumor cells to PARP inhibitors (PARPi), which are selectively toxic to cells that harbor relatively high levels of DNA damage. To address this hypothesis, we evaluated the effect of a BETi (JQ1 or I-BET762) combined with a PARPi (olaparib or ve…
  • Insights into intestinal regeneration signaling mechanisms. [Journal Article]
    Dev Biol 2019Bello SA, Torres-Gutiérrez V, … García-Arrarás JE
  • The cellular mechanisms underlying the amazing ability of sea cucumbers to regenerate their autotomized intestines have been widely described by us and others. However, the signaling pathways that control these mechanisms are unknown. Previous studies have shown that Wnt homologs are upregulated during early intestinal regenerative stages, suggesting that the Wnt/β-catenin pathway is active durin…
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