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145,819 results
  • Effects of alkaline agents on respiratory characteristics in rabbit models of respiratory failure. [Journal Article]
    Respir Physiol Neurobiol. 2020 Jul 02 [Online ahead of print]Yamashita T, Uchiyama A, … Fujino Y
  • This study aimed to investigate the effects of alkaline agents on reducing strong inspiratory effort. Rabbits with hypercapnia or lung injury, induced via repeated lung lavage following injurious ventilation, were treated with Saline, NaHCO3, or Trometamol. In the hypercapnia, minute ventilation and tidal volume were unchanged during NaHCO3 administration; however, one hour after the end of NaHCO…
  • Performance tuning of particle engineered mannitol in dry powder inhalation formulations. [Journal Article]
    Int J Pharm. 2020 Jul 02 [Online ahead of print]Hertel N, Birk G, Scherlieβ R
  • Typically, smooth lactose particles are used as carrier in dry powder formulations for inhalation. Two classical approaches to improve their aerodynamic behaviour are the addition of fines (milled lactose) or magnesium stearate (MgSt). Mannitol (Parteck® M DPI) as an alternative carrier was used in this study. It has an irregular particle size distribution and a large and rough surface. This coul…
  • Exogenous acral pigmentation induced by coleoptera: an underdiagnosed mimic of severe disease. [Journal Article]
    Dermatol Online J. 2020 May 15; 26(5)Álvarez-Salafranca M, Yélamos O, … Ara-Martín M
  • Acral purpura is generally a hallmark for severe internal disease. However, exogenous pigmentation related to contact with invertebrates, can induce acral purpura-like lesions. Data regarding the beetle's ability to cause skin hyperpigmentation or purpura-like lesions are scarce. We report a case of exogenous pigmentation caused by accidental contact with a darkling beetle, clinically simulating …
  • Management of Exercise-Induced Bronchoconstriction in Athletes. [Journal Article]
    J Allergy Clin Immunol Pract. 2020 Jul - Aug; 8(7):2183-2192.Koya T, Ueno H, … Kikuchi T
  • Exercise-induced bronchoconstriction (EIB) is a phenomenon observed in asthma but is also seen in healthy individuals and frequently in athletes. High prevalence rates are observed in athletes engaged in endurance sports, winter sports, and swimming. The pathophysiology of EIB is thought to be related to hyperventilation, cold air, and epithelial damage caused by chlorine and fine particles in in…
  • Bronchial Provocation Testing for the Identification of Exercise-Induced Bronchoconstriction. [Journal Article]
    J Allergy Clin Immunol Pract. 2020 Jul - Aug; 8(7):2156-2164.Brannan JD, Kippelen P
  • Exercise-induced bronchoconstriction (EIB) occurs in patients with asthma, children, and otherwise healthy athletes. Poor diagnostic accuracy of respiratory symptoms during exercise requires objective assessment of EIB. The standardized tests currently available are based on the assumption that the provoking stimulus to EIB is dehydration of the airway surface fluid due to conditioning large volu…
  • Aggregate and cumulative chronic risk assessment for pyrethroids in the French adult population. [Journal Article]
    Food Chem Toxicol. 2020 Jun 30 [Online ahead of print]Vanacker M, Quindroit P, … Crépet A
  • Pyrethroids are commonly used as insecticides in households, in agriculture or in veterinary and medicinal products. This study aimed to assess cumulative aggregate exposure to cyfluthrin, cypermethrin, deltamethrin and permethrin in adults in France and the associated health risk, and to identify major contributions of exposure sources and routes. External chronic exposures were estimated from d…
  • Review of Burden, Clinical Definitions, and Management of COVID-19 Cases. [Journal Article]
    Am J Trop Med Hyg. 2020 Jul 01 [Online ahead of print]McArthur L, Sakthivel D, … Narh CA
  • Our understanding of SARS-CoV-2, the virus responsible for coronavirus disease 2019 (COVID-19), its clinical manifestations, and treatment options continues to evolve at an unparalleled pace. This review sought to summarize the key literature regarding transmission, case definitions, clinical management, and the burden of COVID-19. Our review of the literature showed that SARS-CoV-2 was mainly tr…
  • Nanoparticle-mediated macrophage targeting-a new inhalation therapy tackling tuberculosis. [Journal Article]
    Drug Deliv Transl Res. 2020 Jul 02 [Online ahead of print]Makled S, Boraie N, Nafee N
  • Despite the potent clinical efficacy of linezolid (LNZ) against drug-resistant tuberculosis, its safety and tolerability remain of major concern. Our objective is to develop antitubercular inhalable LNZ nano-embedded microparticles. In this context, LNZ incorporated in non-structured lipid carriers (NLCs) was characterized in terms of colloidal, morphological, thermal, and release profiles. The p…
  • A Ligamentous Agony: Median Arcuate Ligament Syndrome as an Under-Recognized Cause of Abdominal Pain. [Case Reports]
    Cureus. 2020 Jun 27; 12(6):e8865.Manogna D, Gupta A, Seetharaman M
  • Median arcuate ligament (MAL) syndrome (MALS) is a rare clinical entity characterized by chronic abdominal pain resulting from compression of the celiac artery by the MAL. We present a case of MALS with imaging evidence of anterior compression of the celiac artery on expiration, which was relieved on inspiration. A 33-year-old woman presented with intermittent upper abdominal pain since three mon…
  • Ventilation heterogeneity in smokers: role of unequal lung expansion and peripheral lung structure. [Journal Article]
    J Appl Physiol (1985). 2020 Jul 02 [Online ahead of print]Verbanck SAB, Polfliet M, … Vandemeulebroucke J
  • Smoking-induced ventilation heterogeneity measured at the mouth via established washout indices (lung clearance index LCI and alveolar mixing efficiency AME) potentially results from unequal expansion, which can be quantified by CT, and structural changes down to the lung periphery, characterized by CT parametric response mapping indices (PRMfSAD,PRMEmph). By combining CT imaging and N2 washout t…
  • Effects of Smartphone Addiction on Children's Lung Function. [Journal Article]
    Pediatr Int. 2020 Jul 02 [Online ahead of print]Alonazi A, Almutairi W, … Alismail A
  • CONCLUSIONS: Our findings showed that addicted children (when using SAS-SV as an indicator for addiction) revealed lower CVA and lung function results. Therefore, education on proper posture while holding smartphones is essential to the children's postural and lung function status.
  • Nasal IgE in subjects with allergic and non-allergic rhinitis. [Journal Article]
    World Allergy Organ J. 2020 Jun; 13(6):100129.Eckrich J, Hinkel J, … Zielen S
  • CONCLUSIONS: Nasal IgE is present in subjects with HDM allergy, but not in non-allergic rhinitis. In the investigated non-selected population, exclusive local production of IgE is absent. By implication, therefore, our findings challenge the emerging concept of local allergic rhinitis.Study identifier at NCT02810535.
  • Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions. [Journal Article]
    Sci Rep. 2020 Jul 01; 10(1):10741.Ahmed S, Kobayashi H, … Hiraku Y
  • Indium compounds have been widely used in manufacturing displays of mobile phones, computers and televisions. However, inhalation exposure to indium compounds causes interstitial pneumonia in exposed workers and lung cancer in experimental animals. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed under inflammatory conditions and may participate in indium-induced carcinogenesis. In this…
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