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Unbound Medicine.
(insulinemia)
1,617 results
  • Leptin decreases de novo lipogenesis in patients with lipodystrophy. [Journal Article]
    JCI Insight. 2020 Jun 23 [Online ahead of print]Baykal AP, Parks EJ, … Brown RJ
  • De novo lipogenesis (DNL) plays a role in the development of hepatic steatosis. In humans with lipodystrophy, reduced adipose tissue causes lower plasma leptin, insulin resistance, dyslipidemia and ectopic triglyceride (TG) accumulation. We hypothesized that recombinant leptin (metreleptin) for 6 months in 11 patients with lipodystrophy would reduce DNL by decreasing insulin resistance and glycem…
  • m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β Cells. [Journal Article]
    Diabetes. 2020 May 13 [Online ahead of print]Wang Y, Sun J, … Ning G
  • m6A RNA modification is essential during embryonic development of various organs; however, its role in embryonic and early postnatal islet development remains unknown. Mice in which RNA methyltransferase-like 3/14 (Mettl3/14) were deleted in Ngn3+ endocrine progenitors (Mettl3/14 nKO) developed hyperglycemia and hypo-insulinemia at 2 weeks after birth. We found that Mettl3/14 specifically regulat…
  • Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes. [Journal Article]
    Front Endocrinol (Lausanne). 2020; 11:254.Sangalli E, Tagliabue E, … Spinetti G
  • Circulating microRNAs are potential biomarkers of type 2 diabetes mellitus (T2DM) and related complications. Here, we investigated the association of microRNA-15a with early retinal damage in T2DM. A cohort of untreated subjects screened for intermediate/high risk of T2DM, according to a score assessment questionnaire, and then recognized to have a normal (NGT) or impaired (IGT) glucose tolerance…
  • Chemerin predicts carotid intima-media thickening in severe obesity. [Journal Article]
    Eur J Clin Invest. 2020 Apr 29 [Online ahead of print]Ministrini S, Ricci MA, … Lupattelli G
  • CONCLUSIONS: Chemerin is involved in the development and progression of early vascular damage and insulin resistance in subjects with severe obesity, and in their healing after bariatric surgery. Chemerin could also have a role in the assessment of cardiovascular risk in subjects with severe obesity.
  • Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes. [Journal Article]
    FASEB J. 2020 Apr; 34(4):5697-5714.Davey JR, Estevez E, … Gregorevic P
  • Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating pancreatic β-cell function. The pro-inflammatory factor Activin has been implicated as a positive correlate of severity in T2D patients, and as a negative regulator of glucose uptake by skeletal muscle, and of pancreatic β-cell phenotype in mice. Accordingly, we sought to …
  • Akt activation by insulin treatment attenuates cachexia in Walker-256 tumor-bearing rats. [Journal Article]
    J Cell Biochem. 2020 Feb 14 [Online ahead of print]de Fatima Silva F, de Morais H, … de Souza HM
  • Cancer-bearing often exhibits hypoinsulinemia, insulin (INS) resistance and glutamine depletion associated with cachexia. However, INS and glutamine effects on cachexia metabolic abnormalities, particularly on tumor-affected proteins related to INS resistance, are poorly known. The main purpose of this study was to investigate the effects of INS and glutamine dipeptide (GDP) treatments on phospho…
  • Dietary zinc restriction promotes degeneration of the endocrine pancreas in mice. [Journal Article]
    Biochim Biophys Acta Mol Basis Dis. 2020 May 01; 1866(5):165675.Sisnande T, Lima CK, … Lima LMTR
  • Zinc is a key component of several proteins, interacting with the pancreatic hormones insulin and amylin. The role of zinc in insulin oligomerization and crystallinity is well established, although the effects of dietary zinc restriction on both energetic metabolism and β-pancreatic hormonemia and morphology remain unexplored. Here we report the effects of dietary zinc restriction on the endocrin…
  • Glucose and lipid abnormalities in patients with adrenal incidentalomas. [Journal Article]
    Hell J Nucl Med. 2019 Sep-Dec; 22 Suppl 2:7-14.Vukomanovic VR, Ignjatovic VD, … Matovic MD
  • CONCLUSIONS: The present study demonstrates the patients with functional AI have significantly higher lipid, glucose and insulin concentration than controls. There was a significant positive correlation between metabolic parameters and cortisol concentration.
  • Effect of Dietary Insulinemia on All-Cause and Cause-Specific Mortality: Results From a Cohort Study. [Journal Article]
    J Am Coll Nutr. 2019 Nov 25 [Online ahead of print]Mazidi M, Katsiki N, … International Lipid Expert Panel (ILEP)
  • CONCLUSIONS: These findings highlight, for the first time, the detrimental role (association) of insulinemia and insulin resistance potential of diet on all-cause and cause-specific mortality. Our findings support the role of C-peptide and TG/HDL-C ratio as cost-effective and practical biomarkers in clinical settings. These results need to be confirmed to establish their implications.
  • Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms. [Journal Article]
    Front Endocrinol (Lausanne). 2019; 10:757.Scoppola A, Strigari L, … Torino F
  • Insulin resistance and obesity are suggested to have a key role in the molecular pathogenesis of various disorders, including several malignancies. Moreover, insulin resistance has recently been found to be associated with cutaneous and uveal melanoma, while a variable positive correlation between obesity and the risk of cutaneous melanoma was also found at least in men. The present trial aims at…
  • Low-calorie sweeteners cause only limited metabolic effects in mice. [Journal Article]
    Am J Physiol Regul Integr Comp Physiol. 2020 01 01; 318(1):R70-R80.Glendinning JI, Hart S, … Williams N
  • There are widespread concerns that low-calorie sweeteners (LCSs) cause metabolic derangement. These concerns stem in part from prior studies linking LCS consumption to impaired glucose tolerance in humans and rodents. Here, we examined this linkage in mice. In experiment 1, we provided mice with chow, water, and an LCS-sweetened solution (saccharin, sucralose, or acesulfame K) for 28 days and mea…
  • Rho-kinase activity is upregulated in the skeletal muscle of aged exercised rats. [Journal Article]
    Exp Gerontol. 2019 12; 128:110746.Muñoz VR, Gaspar RC, … Pauli JR
  • There is a gap in the knowledge regarding the regulation of glucose uptake in skeletal muscle during the development of insulin resistance in the elderly. Rho-Kinase (Rock) signaling has been demonstrated as a crucial mechanism related to glucose metabolism and insulin sensitivity in skeletal muscle. This kinase is involved in the insulin receptor substrate 1 (IRS1) phosphorylation, leading to gl…
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