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(intelligence quotient)
3,547 results
  • Need of Immediate Drug Reduction after Epilepsy Surgery - A Prospective Observational Study. [Journal Article]
    Neurol India 2019 Jul-Aug; 67(4):1050-1053Bajaj J, Chandra SP, … Tripathi M
  • CONCLUSIONS: Perioperative drug alteration is often needed in the HS patients as compared to TL patients. Benzodiazepines have to be reduced to maintain alertness in the HS patients. The increased sedation postoperatively can be due to decreased cortical drive over the reticular activating system, gamma-aminobutyric acid (GABA) receptor denervation hypersensitivity, or increased activity of drugs over the remaining active hemisphere.
  • Impact of gestational age on child intelligence, attention and executive function at age 5: a cohort study. [Journal Article]
    BMJ Open 2019; 9(9):e028982Sejer EPF, Bruun FJ, … Schiøler Kesmodel U
  • CONCLUSIONS: This study showed substantially lower intelligence and poorer executive function in children born <34 weeks GA compared with children born at term. GA may play an important role in determining cognitive abilities independent of maternal intelligence and parental education. Studies with larger sample sizes are needed to confirm these findings, as the proportion of children born preterm in this study population was small.
  • The Road to Diagnosis: Shortening the Diagnostic Odyssey in Epilepsy. [Journal Article]
    Epilepsy Curr 2019; :1535759719871593Mefford HC
  • CONCLUSIONS: This study illustrates the clinical diagnostic relevance of WES for patients with both epilepsy and ID. It also demonstrates that implementing WES diagnostics might have impact on the (antiepileptic) treatment strategy in this population. Confirmation of variants of uncertain significance in (candidate) genes may further increase the yield. Diagnostic Yield of Genetic Tests in Epilepsy: A Meta-Analysis and Cost-Effectiveness Study Sánchez Fernández I, Loddenkemper T, Gaínza-Lein M, Sheidley BR, Poduri A. Neurology. 2019. Epub ahead of print. pii: 10.1212/WNL.0000000000006850. doi:10.1212/WNL.0000000000006850. PMID: 30610098 Objective: To compare the cost-effectiveness of genetic testing strategies in patients with epilepsy of unknown etiology.Whole-exome sequencing and EP are the most cost-effective genetic tests for epilepsy. Our analyses support for a broad population of patients with unexplained epilepsy, starting with these tests. Although less expensive, CMA has lower yield, and its use as the first-tier test is thus not supported from a cost-effectiveness perspective.
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