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(interferon beta 1b)
1,606 results
  • Site Directed Disulfide PEGylation of Interferon-beta-1b With Fork Peptide Linker. [Journal Article]
    Bioconjug Chem 2020Abbasi S, Farahani H, … Pooyan S
  • The attachment of PEG to biopharmaceuticals has been applied for enhancement of bioavailability and improved stability. The PEG polymer is highly hydrated; thus effective attachment to inaccessible sites could be hindered. We have devised a scheme to address this issue by introducing a considerable distance between PEG and protein by addition of a linear peptide, appended to long chained reactive…
  • Evaluation of clinical prognostic factors in Polish interferon beta-1b treated multiple sclerosis patients. [Journal Article]
    Neurol Neurochir Pol 2019; 53(6):458-465Pietrzak A, Kalinowska-Łyszczarz A, … Michalak S
  • CONCLUSIONS: Rio, modified Rio, early NEDA on treatment and BREMSO score are relatively specific, but insensitive, predictors of relapse activity in the first years of IFNβ-1b treatment. Higher pre-treatment EDSS and relapse activity is associated with disability progression, but not overall NEDA, in subsequent observation. While none of the markers is sufficiently sensitive or specific to make a certain prognosis, they may aid treatment decisions in patients with continued early disease activity.
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Multiple Sclerosis Agents [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Multiple sclerosis is a chronic demyelinating disorder of the central nervous system of unknown etiology. It is most likely caused by a gradual, intermittent autoimmune destruction of myelin. The disorder is characterized by a relapsing-remitting course, but in a small proportion of paitents, it is unremittingly progressive even from the onset. The disease typically presents between the ages of 2…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Beta Interferon [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Interferon beta (β-1a and β-1b) is a cytokine and belongs to a group of naturally occurring proteins which interact with cell surface receptors to produce intracellular antiviral, anti-proliferative, and immuno-modulatory effects. Interferon beta is used commonly to prevent relapses in multiple sclerosis. Interferon beta is a well known cause of mild hepatic injury that occasionally can lead to s…
  • Vitamin D enhances responses to interferon-β in MS. [Journal Article]
    Neurol Neuroimmunol Neuroinflamm 2019; 6(6):e622Feng X, Wang Z, … Reder AT
  • CONCLUSIONS: Vitamin D enhances IFN-β induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-β alone. The combination of vitamin D and IFN-β has potential benefit in ameliorating MS.
  • Functional Deimmunization of Interferon Beta-1b by Identifying and Silencing Human T Cells Epitopes. [Journal Article]
    Iran J Allergy Asthma Immunol 2019; 18(4):427-440Moradi Hasan-Abad A, Adabi E, … Kardar GA
  • Interferonbeta-1b (IFNβ-1b) developed as therapeutic protein for the treatment of multiple sclerosis (MS). Studies have been shown that Long-term usage of this protein can lead to the development of anti-drug antibodies (ADAs) and this phenomenon cause total loss or reduced efficacy of IFNβ-1b. The aim of this study was to predict and silence IFNβ-1b T-cells epitopes by in silico methods and gene…
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