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(interferon beta 1b)
1,600 results
  • Vitamin D enhances responses to interferon-β in MS. [Journal Article]
    Neurol Neuroimmunol Neuroinflamm 2019; 6(6):e622Feng X, Wang Z, … Reder AT
  • CONCLUSIONS: Vitamin D enhances IFN-β induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-β alone. The combination of vitamin D and IFN-β has potential benefit in ameliorating MS.
  • Functional Deimmunization of Interferon Beta-1b by Identifying and Silencing Human T Cells Epitopes. [Journal Article]
    Iran J Allergy Asthma Immunol 2019; 18(4):427-440Moradi Hasan-Abad A, Adabi E, … Kardar GA
  • Interferonbeta-1b (IFNβ-1b) developed as therapeutic protein for the treatment of multiple sclerosis (MS). Studies have been shown that Long-term usage of this protein can lead to the development of anti-drug antibodies (ADAs) and this phenomenon cause total loss or reduced efficacy of IFNβ-1b. The aim of this study was to predict and silence IFNβ-1b T-cells epitopes by in silico methods and gene…
  • Aligned Expression of IFI16 and STING Genes in RRMS Patients' Blood. [Journal Article]
    Endocr Metab Immune Disord Drug Targets 2019Helbi S, Ravanbakhsh B, … Jivad N
  • CONCLUSIONS: Perhaps the IFNβ therapy decreases the IFI16 and STING expression in a STING-dependent pathway as a negative feedback mechanism for regulation of immune system and suppression of pro-inflammatory cytokines production. Important role of DNA sensing molecules and STING-dependent pathway in MS makes a new insight in future treatment based on STING-direct therapies.
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