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(interneuron)
25,284 results
  • Perineuronal nets in the insula regulate aversion-resistant alcohol drinking. [Journal Article]
    Addict Biol 2019; :e12821Chen H, Lasek AW
  • One of the most pernicious characteristics of alcohol use disorder is the compulsion to drink despite negative consequences. The insular cortex controls decision making under conditions of risk or conflict. Cortical activity is tightly controlled by inhibitory interneurons that are often enclosed by specialized extracellular matrix structures known as perineuronal nets (PNNs), which regulate neur…
  • Robust computation with rhythmic spike patterns. [Journal Article]
    Proc Natl Acad Sci U S A 2019Frady EP, Sommer FT
  • Information coding by precise timing of spikes can be faster and more energy efficient than traditional rate coding. However, spike-timing codes are often brittle, which has limited their use in theoretical neuroscience and computing applications. Here, we propose a type of attractor neural network in complex state space and show how it can be leveraged to construct spiking neural networks with r…
  • Impact of High-Dose Caffeine on the Preterm Ovine Cerebrum and Cerebellum. [Journal Article]
    Front Physiol 2019; 10:990Atik A, De Matteo R, … Tolcos M
  • Caffeine is one of the few treatments available for infants with apnea of prematurity. As the recommended dosing regimen is not always sufficient to prevent apnea, higher doses may be prescribed. However, little is currently known about the impact of high-dose caffeine on the developing brain; thus, our aim was to investigate the consequences of a high-dose regimen on the immature ovine brain. Hi…
  • Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2. [Journal Article]
    Proc Natl Acad Sci U S A 2019Wiebe S, Nagpal A, … Sonenberg N
  • Translational control plays a key role in regulation of neuronal activity and behavior. Deletion of the translational repressor 4E-BP2 in mice alters excitatory and inhibitory synaptic functions, engendering autistic-like behaviors. The contribution of 4E-BP2-dependent translational control in excitatory and inhibitory neurons and astrocytic cells to these behaviors remains unknown. To investigat…
  • Acute focal seizures start as local synchronizations of neuronal ensembles. [Journal Article]
    J Neurosci 2019Wenzel M, Hamm JP, … Yuste R
  • Understanding seizure formation and spread remains a critical goal of epilepsy research. We used fast in vivo two-photon calcium imaging in male mouse neocortex to reconstruct, with single cell resolution, the dynamics of acute (4-AP) focal cortical seizures as they originate within a spatially confined seizure initiation site (intrafocal region), and subsequently propagate into neighboring corti…
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