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5,016 results
  • The role of nuclear quantum effects in the relative stability of hexagonal and cubic ice. [Journal Article]
    J Chem Phys 2019; 151(14):144503Buxton SJ, Quigley D, Habershon S
  • At atmospheric pressure, hexagonal ice (Ih) is thermodynamically stable relative to cubic ice (Ic), although the magnitude and underlying physical origin of this stability difference are not well defined. Pure Ic crystals are not accessible experimentally, and hence computer simulations have often been used to interrogate the relative stabilities of Ih and Ic; however, these simulations are domin…
  • Big Data: Why Should Canadian Nurse Leaders Care? [Journal Article]
    Nurs Leadersh (Tor Ont) 2019; 32(2):19-30Remus S, Donelle L
  • Big data using data science methods (data analytics) has the potential to effectively inform strategies to address complex healthcare challenges. However, this potential can only be realized if healthcare professionals have the requisite depth and breadth of knowledge (i.e., informatics competencies). With the emergence of electronic health records (EHRs - commonly known as clinical information s…
  • Unmanned aerial vehicles reveal the impact of a total solar eclipse on the atmospheric surface layer. [Journal Article]
    Proc Math Phys Eng Sci 2019; 475(2229):20190212Bailey SCC, Canter CA, … Smith SW
  • We use unmanned aerial vehicles to interrogate the surface layer processes during a solar eclipse and gain a comprehensive look at the changes made to the atmospheric surface layer as a result of the rapid change of insolation. Measurements of the atmospheric surface layer structure made by the unmanned systems are connected to surface measurements to provide a holistic view of the impact of the …
  • Drivers of α-sheet formation in transthyretin under amyloidogenic conditions. [Journal Article]
    Biochemistry 2019Childers MC, Daggett V
  • Amyloid diseases are a set of fatal disorders in which proteins aggregate to form fibrils that deposit in tissues throughout the body. Amyloid-associated diseases are challenging to study because amyloid formation occurs on timescales that span several orders of magnitude and involve heterogeneous, interconverting protein conformations. The development of more effective technologies to diagnose a…
  • Deciphering host immunity to malaria using systems immunology. [Review]
    Immunol Rev 2019Loiseau C, Cooper MM, Doolan DL
  • A century of conceptual and technological advances in infectious disease research has changed the face of medicine. However, there remains a lack of effective interventions and a poor understanding of host immunity to the most significant and complex pathogens, including malaria. The development of successful interventions against such intractable diseases requires a comprehensive understanding o…
  • Methods for characterizing protein acetylation during viral infection. [Journal Article]
    Methods Enzymol 2019; 626:587-620Murray LA, Combs AN, … Cristea IM
  • Lysine acetylation is a prevalent posttranslational modification that acts as a regulator of protein function, subcellular localization, and interactions. A growing body of work has highlighted the importance of temporal alterations in protein acetylation during infection with a range of human viruses. It has become clear that both cellular and viral proteins are decorated by lysine acetylations,…
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