- DISTINGUISHING INTRARETINAL MICROVASCULAR ABNORMALITIES FROM RETINAL NEOVASCULARIZATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. [Journal Article]Retina 2019R
- CONCLUSIONS: Optical coherence tomography angiography, through flow overlay, has utility to image and differentiate IRMA and NV, which are key features distinguishing severe non-PDR and PDR, respectively. Noninvasive widefield OCTA may be a useful tool to diagnose high-risk diabetic retinopathy eyes.
- Application of optical coherence tomography angiography in diabetic retinopathy: a comprehensive review. [Review]Can J Ophthalmol 2019; 54(5):519-528CJ
- Optical coherence tomography angiography (OCTA) is a noninvasive method that enables visualization of blood flow within retinal vessels down to the size of capillaries by detecting motion contrast from moving blood cells. OCTA provides a fast and safe procedure to assess retinal microvasculature with higher contrast and resolution than conventional fluorescence angiography. The different capillar…
Optical coherence tomography angiography (OCTA) is a noninvasive method that enables visualization of blood flow within retinal vessels down to the size of capillaries by detecting motion contrast from moving blood cells. OCTA provides a fast and safe procedure to assess retinal microvasculature with higher contrast and resolution than conventional fluorescence angiography. The different capillary plexuses are displayed separately and their perfusion density can be quantified. Imaging capabilities such as these have led to an emerging field of clinical application for OCTA in vascular diseases such as diabetic retinopathy (DR). Evaluation of parameters such as parafoveal capillary perfusion density could be a biomarker for disease diagnosis and progression. Typical microvascular changes in DR such as capillary nonperfusion, microaneurysms, intraretinal microvascular abnormalities, and neovascularization can be reliably detected in optical coherence tomography angiograms, characterized in detail and attributed to the different capillary plexuses. Monitoring of these lesions in vivo gives potential novel insight into the pathophysiology in DR. The aim of this article is to summarize the potential applications/utility of OCTA in DR reported in the literature.
- The Oxygen Saturation in Vascular Abnormalities Depends on the Extent of Arteriovenous Shunting in Diabetic Retinopathy. [Journal Article]Invest Ophthalmol Vis Sci 2019; 60(12):3762-3767IO
- CONCLUSIONS: The findings suggest that the oxygen saturation in vascular abnormalities in diabetic retinopathy depends on the extent of arteriovenous (A-V) shunting, with venous saturation due to no A-V shunting in venous loops and reduplications, and intermediate oxygen saturation due to moderate shunting in IRMAs. This may precede the development of neovascularizations with arterial oxygen saturation due to high A-V shunting.
- ETDRS Grading of Diabetic Retinopathy: Still the Gold Standard? [Review]Ophthalmic Res 2019; :1-6OR
- This article aims to provide a narrative history of the evolution, modification, and legacy of the Early Treatment Diabetic Retinopathy Study classification system.
This article aims to provide a narrative history of the evolution, modification, and legacy of the Early Treatment Diabetic Retinopathy Study classification system.
- Comparing diabetic retinopathy lesions in scanning laser ophthalmoscopy and colour fundus photography. [Journal Article]Acta Ophthalmol 2019AO
- CONCLUSIONS: There was good correlation in detected microaneurysms, blot haemorrhages and cotton wool spots between SLO and colour fundus photographs. However, there was intergrader variability in flame haemorrhage, intraretinal microvascular abnormalities, venous beading and neovascularization grading with both modalities.
- Combined Multimodal Analysis of Peripheral Retinal and Macular Circulation in Diabetic Retinopathy (COPRA Study). [Journal Article]Ophthalmol Retina 2019; 3(7):580-588OR
- CONCLUSIONS: OCTA metrics are indicators of the severity of peripheral retinal nonperfusion. However, the central ischemic index did not exhibit a linear relationship with peripheral capillary nonperfusion. Our findings suggest that a rise in intraocular vascular endothelial growth factor as a consequence of mild peripheral capillary nonperfusion may play a compensatory role in maintaining the central macular microcirculation. Further investigations with studies employing longitudinal design will improve our understanding of the relationship between macular microcirculation and peripheral ischemia.
- Recent advances in the diagnosis and treatment of Coats' disease. [Review]Int Ophthalmol 2019; 39(4):957-970IO
- CONCLUSIONS: Early diagnosis and timely treatment based on clinical stage are critical to retaining the patient's visual function. Patients should be aware that close long-term follow-up is necessary.
- [Anatomo-functional study in branch retinal vein occlusion using Swept Source Optical Coherence Tomography Angiography]. [Journal Article]J Fr Ophtalmol 2019; 42(3):255-261JF
- CONCLUSIONS: OCT-angiography is part of the current diagnostic workup for RVO. It has a relevant role in establishing a prognosis by studying the area of the FAZ and the capillary density.
- An Automated Grading System for Detection of Vision-Threatening Referable Diabetic Retinopathy on the Basis of Color Fundus Photographs. [Journal Article]Diabetes Care 2018; 41(12):2509-2516DC
- CONCLUSIONS: This artificial intelligence-based DLA can be used with high accuracy in the detection of vision-threatening referable DR in retinal images. This technology offers potential to increase the efficiency and accessibility of DR screening programs.
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- Retinal flow density by optical coherence tomography angiography is useful for detection of nonperfused areas in diabetic retinopathy. [Journal Article]Graefes Arch Clin Exp Ophthalmol 2018; 256(12):2275-2282GA
- CONCLUSIONS: FD measurement in OCTA is useful for NPA detection in DR.