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(intravitreal intravitreous)
270 results
  • Xy31Prefilled syringes for intravitreal drug delivery. [Review]
    Clin Ophthalmol 2019; 13:701-706Sassalos TM, Paulus YM
  • Intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications play an increasingly critical role in numerous retinal vascular diseases. Initially, anti-VEGF medications came in vials that had to be drawn up by the physician into a syringe for administration. In 2018, the US Food and Drug Administration (US FDA) approved the ranibizumab 0.3 mg prefilled syringe (PFS), and i…
  • Anti-vascular endothelial growth factor for neovascular age-related macular degeneration. [Meta-Analysis]
    Cochrane Database Syst Rev 2019; 3:CD005139Solomon SD, Lindsley K, … Hawkins BS
  • CONCLUSIONS: Results of this review show the effectiveness of anti-VEGF agents (pegaptanib, ranibizumab, and bevacizumab) in terms of maintaining visual acuity; studies show that ranibizumab and bevacizumab improved visual acuity in some eyes that received these agents and were equally effective. Available information on the adverse effects of each medication does not suggest a higher incidence of potentially vision-threatening complications with intravitreous injection of anti-VEGF agents compared with control interventions; however, clinical trial sample sizes were not sufficient to estimate differences in rare safety outcomes. Future Cochrane Reviews should incorporate research evaluating variable dosing regimens of anti-VEGF agents, effects of long-term use, use of combination therapies (e.g. anti-VEGF treatment plus photodynamic therapy), and other methods of delivering these agents.
  • In vivo effect of acute exposure to interleukin-6 on the developing visual system. [Journal Article]
    Neurosci Lett 2019; 698:7-12Menezes GD, Faria-Melibeu AC, … Campello-Costa P
  • Interleukin-6 (IL-6) is involved in different processes of the central nervous system. Our aims were to investigate the effect of IL-6 on retinotectal topography and on different signaling pathways. Rats were submitted to an intravitreous injection of either IL-6 (50 ng/ml) or PBS (vehicle) at postnatal day 10 (PND10). At PND11 or PND14, different groups were processed for western blot, histochem…
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