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162,942 results
  • StatPearls: Histology, Parietal Cells [BOOK]
    StatPearls Publishing: Treasure Island (FL) Varela Carlos D. CD ITESM Segura Nancy N BOOK
  • Unique to the human body due to its acid-secreting ability, the parietal cell has always been a subject of interest for scientific research. Harbored in the gastric glands of the fundus and body, parietal cells are considered to be dynamic, as they undergo morphological transition during the resting and secretory states.[1][2] Parietal cells play a pivotal role in gastric homeostasis, as well as …
  • Low-distortion diffusion tensor MRI with improved phaseless encoding. [Journal Article]
    J Magn Reson 2019; 309:106602Tian R, Hennel F, Pruessmann KP
  • Due to the motion-related instability of the signal phase, diffusion MRI is usually performed with single-shot techniques such as the echo-planar imaging (EPI), which are resolution-limited and suffer from distortions caused by resonance offsets. Multi-shot methods may improve the images but require time-consuming navigators or a trade-off of the sensitivity encoding to measure shot-dependent pha…
  • Visual novelty, curiosity, and intrinsic reward in machine learning and the brain. [Review]
    Curr Opin Neurobiol 2019; 58:167-174Jaegle A, Mehrpour V, Rust N
  • A strong preference for novelty emerges in infancy and is prevalent across the animal kingdom. When incorporated into reinforcement-based machine learning algorithms, visual novelty can act as an intrinsic reward signal that vastly increases the efficiency of exploration and expedites learning, particularly in situations where external rewards are difficult to obtain. Here we review parallels bet…
  • Phloretin as both a substrate and inhibitor of tyrosinase: Inhibitory activity and mechanism. [Journal Article]
    Spectrochim Acta A Mol Biomol Spectrosc 2019; 226:117642Chen J, Li Q, … Jin N
  • Tyrosinase is the rate-limiting enzyme for controlling the production of melanin in the human body, and overproduction of melanin can lead to a variety of skin disorders. In this paper, the inhibitory kinetics of phloretin on tyrosinase and their binding mechanism were determined using spectroscopy, molecular docking, antioxidant assays and chromatography. The spectroscopic results indicate that …
  • Newly formulated 5% 5-aminolevulinic acid phototherapy on Candida albicans. [Journal Article]
    Photodiagnosis Photodyn Ther 2019Greco G, Di Piazza S, … Amaroli A
  • CONCLUSIONS: The 5%ALA-PTt preparation was shown to be effective in reducing the growth of biofilm and inoculum of C. albicans. This effect seems to be linked to the intrinsic characteristics of 5%ALA-TPt, such acidic pH and the induction of free radical production. This outcome was significantly enhanced by the effect of PT at relatively short incubation and irradiation times, which resulted in growth inhibition of both treated biofilm and inoculum by ⿼80% and ⿼95%, respectively.
  • A Network Pharmacology Approach to Explore the Mechanisms of Qishen Granules in Heart Failure. [Journal Article]
    Med Sci Monit 2019; 25:7735-7745Liu J, Li Y, … Wang W
  • This study aimed to investigate the intrinsic mechanisms of Qishen granules (QSG) in the treatment of HF, and to provide new evidence and insights for its clinical application. Information on QSG ingredients was collected from Traditional Chinese medicine systems pharmacology (TCMSP), TCM@Taiwan, TCMID, and Batman, and input into SwissTargetPrediction to identify the compound targets. HF-related …
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