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10,568 results
  • Phages Enter the Fight against Colorectal Cancer. [Journal Article]
    Trends Cancer 2019; 5(10):577-579Kannen V, Parry L, Martin FL
  • Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC ce…
  • From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer. [Review]
    Nat Rev Clin Oncol 2019Nevala-Plagemann C, Hidalgo M, Garrido-Laguna I
  • Improvements in the outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) have lagged behind advances made in the treatment of many other malignancies over the past few decades. For most patients with PDAC, cytotoxic chemotherapy remains the mainstay of treatment. For patients with resectable disease, modified 5-fluorouracil, leucovorin, irinotecan and oxaliplatin (mFOLFIRINOX) is the…
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