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222,703 results
  • IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. [Journal Article]
    Sci Rep 2019; 9(1):13574Catanzaro JR, Strauss JD, … Palm NW
  • Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possibility that mucosal secretion of IgM can compensate for a lack of secretory IgA. …
  • Adaption of human antibody λ and κ light chain architectures to CDR repertoires. [Journal Article]
    Protein Eng Des Sel 2019van der Kant R, Bauer J, … Schymkowitz J
  • Monoclonal antibodies bind with high specificity to a wide range of diverse antigens, primarily mediated by their hypervariable complementarity determining regions (CDRs). The defined antigen binding loops are supported by the structurally conserved β-sandwich framework of the light chain (LC) and heavy chain (HC) variable regions. The LC genes are encoded by two separate loci, subdividing the en…
  • Fabrication of Microarrays for the Analysis of Serological Antibody Isotypes against Food Antigens. [Journal Article]
    Sensors (Basel) 2019; 19(18)Ryu J, Kim S, … Kwon Y
  • Food intolerance is delayed adverse food reactions which follow consumption of specific foods. The underlying mechanisms are not well understood, but food intolerance is often considered as a type 2 hypersensitivity reaction mediated by immunoglobulin G (IgG) antibody. To understand the causes of food intolerance, it is important to investigate sensitization patterns of food-specific IgGs (sIgG) …
  • Current insights into the mechanism of mammalian immunoglobulin class switch recombination. [Journal Article]
    Crit Rev Biochem Mol Biol 2019; :1-19Yu K, Lieber MR
  • Immunoglobulin (Ig) class switch recombination (CSR) is the gene rearrangement process by which B lymphocytes change the Ig heavy chain constant region to permit a switch of Ig isotype from IgM to IgG, IgA, or IgE. At the DNA level, CSR occurs via generation and joining of DNA double strand breaks (DSBs) at intronic switch regions located just upstream of each of the heavy chain constant regions.…
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