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9,729 results
  • Prediction of bioequivalence and food effect using flux and solubility based methods. [Journal Article]
    Mol Pharm 2019Borbas E, K Aacute D Aacute R S, … Pataki H
  • In this paper two different approaches have been developed to predict the food effect and the bioequivalence of marketed itraconazole (ITRA) formulations. The kinetic solubility and simultaneous dissolution-permeation tests of three (ITRA) formulations (Sporanox capsule and solution, and SUBA-ITRA capsule) were carried out in simulated fasted and fed state. Fraction of dose absorbed ratios estima…
  • Multi-target drugs active against leishmaniasis: A paradigm of drug repurposing. [Journal Article]
    Eur J Med Chem 2019; 183:111660Braga SS
  • This mini-review focuses on leishmanicidal drugs that were sourced from small molecules previously approved for other diseases. The mechanisms of action of these molecules are herein explored, to probe the origins of their inter-species growth inhibitory activities. It is shown how the transversal action of the azoles - fluconazole, posaconazole and itraconazole - in both fungi and Leishmania is …
  • Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia. [Journal Article]
    Med Mycol 2019Surja SS, Adawiyah R, … Wahyuningsih R
  • We performed morphology, molecular study and antifungal susceptibility test on 10 Talaromyces sp. isolates: eight clinical isolates (human immunodeficiency virus (HIV) and non-HIV-patient) and two isolates from rats. All strains produced red soluble pigment and microscopically showed Penicillium-like structure in room temperature and yeast-like structure in 37°C. Based on molecular analysis, nine…
  • Oral histoplasmosis masquerading as acute necrotizing ulcerative gingivitis: A rare case report. [Case Reports]
    Int J Health Sci (Qassim) 2019 Sep-Oct; 13(5):37-40Khetarpal S, Mhapsekar T, … Parihar A
  • Histoplasmosis also called as "Darling's Disease" is a community-acquired primary pulmonary disease caused by inhalation of dust containing spores of soil-dwelling dimorphic fungi, Histoplasma capsulatum. Presentation of fungi in the oral cavity is usually rare and is generally associated with an immunocompromised state. Here, we present a rare case of histoplasmosis in an immunocompetent patient…
  • Trichophyton rubrum azole resistance mediated by a new ABC transporter, TruMDR3. [Journal Article]
    Antimicrob Agents Chemother 2019Monod M, Feuermann M, … Yamada T
  • Mechanisms of terbinafine resistance in a set of clinical isolates of Trichophyton rubrum have been studied recently. Of these isolates, TIMM20092 also showed reduced sensitivity to azoles. The azole resistance of TIMM20092 could be inhibited by milbemycin oxime, prompting us to examine the potential of T. rubrum to develop resistance through multidrug efflux transporters. The introduction of a T…
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