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9,906 results
  • The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. [Journal Article]
    Nat Commun 2020; 11(1):427Furukawa T, van Rhijn N, … Bromley MJ
  • The frequency of antifungal resistance, particularly to the azole class of ergosterol biosynthetic inhibitors, is a growing global health problem. Survival rates for those infected with resistant isolates are exceptionally low. Beyond modification of the drug target, our understanding of the molecular basis of azole resistance in the fungal pathogen Aspergillus fumigatus is limited. We reasoned t…
  • Anti-angiogenesis by dual action of R5K peptide conjugated itraconazole nanoparticles. [Journal Article]
    AAPS PharmSciTech 2020; 21(3):74Chittasupho C, Kengtrong K, … Sarisuta N
  • Neovascular age-related macular degeneration (AMD) is a leading cause of central vision loss and irreversible blindness. Vascular endothelial growth factor (VEGF) plays an important role in neovascularization under the retina and macula by promoting endothelial cell proliferation, migration, and angiogenesis. Although anti-VEGF drugs have shown their efficacy in visual improvement, long-term use …
  • Successful treatment of chromoblastomycosis caused by Fonsecaea pedrosoi using imiquimod. [Journal Article]
    J Dermatol 2020Belda W, Criado PR, Passero LFD
  • Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as physical approaches, is considered complex and ineffective due to the high rate of relapses. Thus, new strategies are needed to manage CBM; in this regard, the present work report…
  • Paper-based sol-gel thin films immobilized cytochrome P450 for enzyme activity measurement. [Journal Article]
    Anal Chim Acta 2020; 1098:86-93Nuchtavorn N, Leanpolchareanchai J, … Macka M
  • Cytochrome P450 (CYP450), and in particular CYP3A4, is the most abundantly expressed CYP450 isozyme implicated in many drug-drug and medicinal plant-drug interactions. Therefore, incorporation of CYP3A4 enzyme screening at an early stage of drug discovery is preferable in order to avoid enzymatic interactions. Here we present for the first time a paper-based CYP3A4 immobilized sol-gel-derived a p…
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