- Toward Understanding the Mammalian Zygoma: Insights From Comparative Anatomy, Growth and Development, and Morphometric Analysis. [Review]
- ARAnat Rec (Hoboken) 2017; 300(1):76-151
- The zygoma, or jugum, is a cranial element that was present in Mesozoic tetrapods, well before the appearance of mammals. Although as an entity the zygoma is a primitive retention among mammals, it h…
The zygoma, or jugum, is a cranial element that was present in Mesozoic tetrapods, well before the appearance of mammals. Although as an entity the zygoma is a primitive retention among mammals, it has assumed myriad configurations as this group diversified. As the zygoma is located at the intersection of the visual, respiratory, and masticatory apparatuses, it is potentially of great importance in systematic, phylogenetic, and functional studies focused on this region. For example, the facial component of the zygoma and its contribution to a postorbital bar (POB) appear to be relevant to the systematics of a number of mammalian subclades, and the formation of a bony postorbital septum (POS) that separates the orbit from the infratemporal fossa is unique to, and thus potentially phylogenetically significant for uniting anthropoid primates, while the zygoma itself appears to serve to resist tension and bending forces during mastication. In order to better understand the zygoma in the context of its contributions to the circumorbital region, we documented its morphological expression in specimens representing 10 orders of mammals. Since the presence of a POB and of a POS has long been used to justify uniting extant primates and anthropoid primates as respective clades, and because postorbital closure (POC) is morphologically more complex than a POB, we provide detail necessary to address these claims. Our taxically broad overview also allowed us to provide for the first time definitions of configurations that can be applied to future studies. Using a different, but also taxically broad sample of mammals, and of primates in particular, we performed two geometric morphometric analyses that were geared toward testing long-held interpretations of the functional role of the zygoma, especially with regard to mastication and in the context of orbital frontation (to which the zygoma contributes). Further, overall, zygomatic morphology tends not to scale with allometry, sexual dimorphism, or angle of orbital convergence, but it does contribute to unique patterns of intraspecies variation. Anat Rec, 300:76-151, 2017. © 2016 Wiley Periodicals, Inc.
- The Effects of Septal Deviation, Concha Bullosa, and Their Combination on the Depth of Posterior Palatal Arch in Cone-Beam Computed Tomography. [Journal Article]
- JDJ Dent (Shiraz) 2016; 17(1):26-31
- CONCLUSIONS: Based on the findings of this study, simultaneous occurrence of SD and CB influenced the depth and curve of the palatal bone. The PAD/PIL ratio was negatively correlated with the DSCA angle. This correlation was associated with a decrease in PAD, indicating that concurrent occurrence of SD and CB remarkably affected the palatal base of maxilla.
- Update on endoscopic endonasal resection of skull base meningiomas. [Journal Article]
- IFInt Forum Allergy Rhinol 2015; 5(4):344-52
- CONCLUSIONS: Using a 2-team approach, meningiomas of the skull base were successfully removed via an intranasal endoscopic technique. Although complete resection is typically possible even with large tumors, the lengthy resection required time for tumors larger than 60 cm(3) (diameter ≥4 cm) may obviate some of the advantages of this approach. The rate of postoperative CSF leak decreases when a synthetic dural substitute is added but does not approach zero.
- Endoscopic endonasal resection of anterior skull base meningiomas. [Journal Article]
- OHOtolaryngol Head Neck Surg 2012; 147(3):575-82
- CONCLUSIONS: ACF meningiomas can be safely removed endonasally, offering significant advantages over the traditional transcranial approach for suitable tumors. Early audit of this approach shows results achieved by this unit are comparable with the published literature.
- Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. [Multicenter Study]
- CCClin Cancer Res 2011 May 15; 17(10):3368-77
- CONCLUSIONS: Stathmin immunohistochemical staining identifies endometrial carcinomas with lymph node metastases and poor survival. The value, as a predictive marker for response to PI3Kinase inhibition and as a tool to stratify patients for lymph node sampling in endometrial carcinomas, remains to be determined.
- Sectional anatomy of the olfactory pathways. [Journal Article]
- JNJ Neurosurg Sci 2010; 54(1):39-44
- CONCLUSIONS: The olfactory bulb and olfactory tract lay tightly on the ethmoidal cribriform plate and jugum sphenoidale, in the olfactory cistern of the shallow part of the olfactory sulcus, the ethmoid sinus and sphenoid sinus inferiorly.
- The anatomy and systematic position of the early Miocene proconsulid from Meswa Bridge, Kenya. [Journal Article]
- JHJ Hum Evol 2009; 56(5):479-96
- A small collection of fossil catarrhines was recovered from the early Miocene locality of Meswa Bridge in western Kenya between 1978 and 1980. The associated fauna from Meswa Bridge indicates an age …
A small collection of fossil catarrhines was recovered from the early Miocene locality of Meswa Bridge in western Kenya between 1978 and 1980. The associated fauna from Meswa Bridge indicates an age older than 20 Ma. Much of the material has been briefly described previously, and its taxonomic status considered. The material can be assigned to a minimum of four individuals, all of which are infants or juveniles. Although the specimens were shown to belong to a distinct species of Proconsul, the taxon was not named, primarily because many of the specimens belonged to immature individuals. Nevertheless, the combined morphological features of the deciduous and permanent teeth allow the diagnosis of a new species of Proconsul, which is formally named here as P. meswae. It is a large-sized species, similar in dental size to P. nyanzae. The main features distinguishing it from all other previously named species of Proconsul are: incisors and deciduous incisors relatively low crowned; upper deciduous canines relatively higher crowned and more robust; molars and deciduous premolars relatively broader and higher crowned, with a more pronounced degree of buccolingual flare and better developed cingula; size differential between molars not as marked; dP(4) with a longer mesial fovea and smaller hypoconulid and distal fovea; P(4) relatively broader, with a better developed buccal cingulum; lower molars less rectangular with a longer mesial fovea, smaller distal fovea, more restricted talonid basin, and a tendency for a smaller hypoconulid; dP(4) and upper molars with strongly buccolingually splayed roots; mandibular corpus in infants relatively deeper and more slender; maxilla with a well developed canine jugum and fossa. The broader and more flared molars with better developed cingula indicate that the Meswa Bridge species is more primitive than other species of Proconsul. The inference that it is a stem member of the Proconsul clade is consistent with the estimated age of the material.
- Acromegaly due to a growth hormone-releasing hormone-secreting intracranial gangliocytoma. [Case Reports]
- JEJ Endocrinol Invest 2005; 28(2):162-5
- In more than 95% of cases acromegaly is due to GH hypersecretion by a pituitary adenoma. GHRH hypersecretion accounts for about 0.5% of cases of acromegaly. Intracranial GHRH-secreting tumors are ext…
In more than 95% of cases acromegaly is due to GH hypersecretion by a pituitary adenoma. GHRH hypersecretion accounts for about 0.5% of cases of acromegaly. Intracranial GHRH-secreting tumors are extremely rare and only a few well-documented cases have been reported. The clinical features of acromegaly due to intracranial GHRH-secreting tumor are indistinguishable from those of other patients with "classical acromegaly". In cases of intrasellar gangliocytomas, not even radiological findings help to make the correct diagnosis, which can only be made with the hystological study. We present the case of a woman with acromegaly; the magnetic resonance demonstrated a 2x1.8x1.2 cm mass in the jugum sphenoidalis region, associated with a partial empty sella. There was a partial response to high-dose lanreotide therapy, so surgical treatment was decided, although only part of the tumor could be removed. Histopathological diagnosis was consistent with gangliocytoma, and immunostaining in the ganglionic cells was positive for GHRH. After surgery, hormone hypersecretion persisted, so medical treatment was reintroduced. In summary, we report a well-documented case of an intracranial GHRH-secreting gangliocytoma, an exceedingly rare cause of acromegaly. Clinical and biochemical data did not allow to make the correct diagnosis, which was only made on the pathological study. This case underscores that acromegaly can be due to causes other than a GH-secreting adenoma, and underlines that finding an image not typical of a pituitary adenoma should raise the suspicion that an unusual cause subsides the acromegaly.
- The sequence in appearance and disappearance of impressiones gyrorum cerebri and cerebelli. [Journal Article]
- CAColl Antropol 2004; 28(2):849-55
- We investigated the sequence and the intensity in the appearance and the disappearance of the impressiones gyrorum cerebri and cerebelli, of juga cerebralia and cerebellaria and of juga cerebellaria …
We investigated the sequence and the intensity in the appearance and the disappearance of the impressiones gyrorum cerebri and cerebelli, of juga cerebralia and cerebellaria and of juga cerebellaria interlobularia in the collection of 34 macerated and disarticulated skull bones from the newborn to 30 years of age (68 specimens/halves of skulls) and 19 skulls in the period from 30 to 80 years of age (38 specimens). Juga cerebralia on the squama of the temporal bone and cerebral lamina of the frontal bone appeared already in the course of the first year of life, much earlier than cited in the literature. The intensity of the development of juga cerebralia increased to the third decade. After that age, the intensity decreased gradually, and the juga cerebralia disappeared completely in parietal bones, in the cerebral fossae of the occipital bones and finally in most cases also on the cerebral lamina of the frontal bones. Juga cerebellaria and impressiones gyrorum cerebelli appeared in the middle of the second year of age and persisted to the ten years of age, which coincides with the closure of the fissures among the parts of the occipital bone. Jugum cerebellare intersemilunare appeared in the first year of life and persisted in its complete length, or interrupted in different sections of its course, during the whole life. The intensity in appearance of juga is partly influenced by the increasing thickness of the diploe.
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- Ossifying fibroma of the jugum sphenoidale. [Journal Article]
- JCJ Clin Neurosci 2004; 11(5):544-6
- We report a rare case of an eight year old boy with an ossifying fibroma of the jugum sphenoidale who presented with rapid onset bilateral blindness. This benign tumour was initially debulked and req…
We report a rare case of an eight year old boy with an ossifying fibroma of the jugum sphenoidale who presented with rapid onset bilateral blindness. This benign tumour was initially debulked and required re-operation with decompression of both optic nerves due to progressive visual deterioration. Post-operatively, there was good visual recovery in the left eye, but visual acuity in the right eye remained at <1/60. A 17 years follow period is described, in which there has been no clinical or radiological evidence of tumour recurrence.