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(kD kDa)
2,048 results
  • A behavior-based drug screening system using a Caenorhabditis elegans model of motor neuron disease. [Journal Article]
    Sci Rep 2019; 9(1):10104Ikenaka K, Tsukada Y, … Mori I
  • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons, for which there is no effective treatment. Previously, we generated a Caenorhabditis elegans model of ALS, in which the expression of dnc-1, the homologous gene of human dynactin-1, is knocked down (KD) specifically in motor neurons. This dnc-1 KD model showed progressi…
  • The mineralocorticoid receptor contributes to barrier function of a model fish gill epithelium. [Journal Article]
    J Exp Biol 2019; 222(Pt 11)Kolosov D, Kelly SP
  • Cortisol-induced epithelial tightening of a primary cultured rainbow trout gill epithelium model occurs in association with reduced paracellular permeability and increased abundance of select barrier-forming tight junction (TJ) proteins. Corticosteroid receptor (CR) pharmacological blocker studies have suggested that to produce this tightening effect, cortisol acts on the mineralocorticoid recept…
  • Evaluation of PSMA-Targeted PAMAM Dendrimer Nanoparticles in a Murine Model of Prostate Cancer. [Journal Article]
    Mol Pharm 2019; 16(6):2590-2604Lesniak WG, Boinapally S, … Pomper MG
  • The prostate-specific membrane antigen (PSMA) is a validated target for detection and management of prostate cancer (PC). It has also been utilized for targeted drug delivery through antibody-drug conjugates and polymeric micelles. Polyamidoamine (PAMAM) dendrimers are emerging as a versatile platform in a number of biomedical applications due to their unique physicochemical properties, including…
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