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268 results
  • Cellular dynamics of double fertilization and early embryogenesis in flowering plants. [Review]
    J Exp Zool B Mol Dev Evol. 2020 Jul 08 [Online ahead of print]Shin JM, Yuan L, … Kawashima T
  • Flowering plants (angiosperms) perform a unique double fertilization in which two sperm cells fuse with two female gamete cells in the embryo sac to develop a seed. Furthermore, during land plant evolution, the mode of sexual reproduction has been modified dramatically from motile sperm in the early-diverging land plants, such as mosses and ferns as well as some gymnosperms (Ginkgo and cycads) to…
  • Plasmogamic Paternal Contributions to Early Zygotic Development in Flowering Plants. [Review]
    Front Plant Sci. 2020; 11:871.Ohnishi Y, Kawashima T
  • Flowering plant zygotes possess complete developmental potency, and the mixture of male and female genetic and cytosolic materials in the zygote is a trigger to initiate embryo development. Plasmogamy, the fusion of the gamete cytoplasms, facilitates the cellular dynamics of the zygote. In the last decade, mutant analyses, live cell imaging-based observations, and direct observations of fertilize…
  • Sexual Differentiation Is Coordinately Regulated by Cryptococcus neoformans CRK1 and GAT1. [Journal Article]
    Genes (Basel). 2020 Jun 19; 11(6)Liu KH, Shen WC
  • The heterothallic basidiomycetous fungus Cryptococcus neoformans has two mating types, MATa and MATα. Morphological progression of bisexual reproduction in C. neoformans is as follows: yeast to hyphal transition, filament extension, basidium formation, meiosis, and sporulation. C. neoformans Cdk-related kinase 1 (CRK1) is a negative regulator of bisexual mating. In this study, we characterized th…
  • The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition. [Journal Article]
    PLoS Genet. 2020 03; 16(3):e1008543.Torres-Campana D, Kimura S, … Loppin B
  • Following fertilization of a mature oocyte, the formation of a diploid zygote involves a series of coordinated cellular events that ends with the first embryonic mitosis. In animals, this complex developmental transition is almost entirely controlled by maternal gene products. How such a crucial transcriptional program is established during oogenesis remains poorly understood. Here, we have perfo…
  • Polyspermy in angiosperms: Its contribution to polyploid formation and speciation. [Review]
    Mol Reprod Dev. 2020 03; 87(3):374-379.Toda E, Okamoto T
  • Polyploidization has played a major role in the long-term diversification and evolutionary success of angiosperms. Triploid formation among diploid plants, which is generally considered to be achieved by fertilization of an unreduced gamete with a reduced one, has been accepted as a means of polyploid production. In addition, it has been supposed that polyspermy also contributes to the triploid f…
  • Evolutionary Proteomics Reveals Distinct Patterns of Complexity and Divergence between Lepidopteran Sperm Morphs. [Journal Article]
    Genome Biol Evol. 2019 07 01; 11(7):1838-1846.Whittington E, Karr TL, … Walters JR
  • Spermatozoa are one of the most strikingly diverse animal cell types. One poorly understood example of this diversity is sperm heteromorphism, where males produce multiple distinct morphs of sperm in a single ejaculate. Typically, only one morph is capable of fertilization and the function of the nonfertilizing morph, called parasperm, remains to be elucidated. Sperm heteromorphism has multiple i…
  • Sperm Entry into the Egg Cell Induces the Progression of Karyogamy in Rice Zygotes. [Journal Article]
    Plant Cell Physiol. 2019 Aug 01; 60(8):1656-1665.Ohnishi Y, Kokubu I, … Okamoto T
  • Karyogamy is a prerequisite event for plant embryogenesis, in which dynamic changes in nuclear architecture and the establishment of appropriate gene expression patterns must occur. However, the precise role of the male and female gametes in the progression of karyogamy still remains elusive. Here, we show that the sperm cell possesses the unique property to drive steady and swift nuclear fusion.…
  • Plasmodial slime molds and the evolution of microbial husbandry. [Journal Article]
    Theory Biosci. 2019 May; 138(1):127-132.Kutschera U, Hoppe T
  • Detailed analyses into the life cycle of the soil-dwelling microbe Dictyostelium discoideum led to the conclusion that this "social amoeba" practices some form of "non-monoculture farming" via the transfer of bacteria to novel environments. Herein, we show that in myxomycetes (plasmodial slime molds or myxogastrids) a similar "farming symbiosis" has evolved. Based on laboratory studies of two rep…
  • Comparative Genomics Supports Sex and Meiosis in Diverse Amoebozoa. [Journal Article]
    Genome Biol Evol. 2018 11 01; 10(11):3118-3128.Hofstatter PG, Brown MW, Lahr DJG
  • Sex and reproduction are often treated as a single phenomenon in animals and plants, as in these organisms reproduction implies mixis and meiosis. In contrast, sex and reproduction are independent biological phenomena that may or may not be linked in the majority of other eukaryotes. Current evidence supports a eukaryotic ancestor bearing a mating type system and meiosis, which is a process exclu…
  • Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization. [Journal Article]
    Nature. 2018 08; 560(7718):397-400.Vještica A, Merlini L, … Martin SG
  • The ploidy cycle, which is integral to sexual reproduction, requires meiosis to halve chromosome numbers as well as mechanisms that ensure zygotes are formed by exactly two partners1-4. During sexual reproduction of the fungal model organism Schizosaccharomyces pombe, haploid P and M cells fuse to form a diploid zygote that immediately enters meiosis5. Here we reveal that rapid post-fusion recons…
  • Sperm morphology and the evolution of intracellular sperm-egg interactions. [Journal Article]
    Ecol Evol. 2018 May; 8(10):5047-5058.Southern HM, Berger MA, … Snook RR
  • Sperm morphology is incredibly diverse, even among closely related species, yet the coevolution between males and females of fertilization recognition systems is necessary for successful karyogamy (male and female pronuclear fusion). In most species, the entire sperm enters the egg during fertilization so sperm morphological diversity may impact the intracellular sperm-egg interactions necessary …
  • Repeat-induced point (RIP) mutation in the industrial workhorse fungus Trichoderma reesei. [Review]
    Appl Microbiol Biotechnol. 2018 Feb; 102(4):1567-1574.Li WC, Chen CL, Wang TF
  • Trichoderma reesei (syn. Hypocrea jecorina) is a filamentous ascomycete. Due to its capability of producing large amounts of lignocellulolytic enzymes and various heterologous proteins, this fungus has been widely used for industrial applications for over 70 years. It is also a model organism for lignocellulosic biomass degradation and metabolic engineering. Recently, we experimentally and comput…
  • Cell cycle in egg cell and its progression during zygotic development in rice. [Journal Article]
    Plant Reprod. 2018 03; 31(1):107-116.Sukawa Y, Okamoto T
  • Rice egg is arrested at G1 phase probably by OsKRP2. After fusion with sperm, karyogamy, OsWEE1-mediated parental DNA integrity in zygote nucleus, zygote progresses cell cycle to produce two-celled embryo. In angiosperms, female and male gametes exist in gametophytes after the complementation of meiosis and the progression of nuclear/cell division of the haploid cell. Within the embryo sac, the e…
  • Delayed Encounter of Parental Genomes Can Lead to Aneuploidy in Saccharomyces cerevisiae. [Journal Article]
    Genetics. 2018 01; 208(1):139-151.Tartakoff AM, Dulce D, Landis E
  • We have investigated an extreme deviation from the norm of genome unification that occurs during mating in the yeast, Saccharomyces cerevisiae This deviation is encountered when yeast that carry a mutation of the spindle pole body protein, Kar1, are mated with wildtype cells. In this case, nuclear fusion is delayed and the genotypes of a fraction of zygotic progeny suggest that chromosomes have "…
  • Genetic Evidence for Sexuality in Cochliopodium (Amoebozoa). [Journal Article]
    J Hered. 2017 10 30; 108(7):769-779.Wood FC, Heidari A, Tekle YI
  • Microbial eukaryotes, including amoeboids, display diverse and complex life cycles that may or may not involve sexual reproduction. A recent comprehensive gene inventory study concluded that the Amoebozoa are ancestrally sexual. However, the detection of sex genes in some lineages known for their potentially sexual life cycle was very low. Particularly, the genus Cochliopodium, known to undergo a…
  • Schizosaccharomyces japonicus: A Distinct Dimorphic Yeast among the Fission Yeasts. [Journal Article]
    Cold Spring Harb Protoc. 2017 Dec 01; 2017(12):pdb.top082651.Aoki K, Furuya K, Niki H
  • Genomic sequencing data and morphological properties demonstrate evolutionary relationships among groups of the fission yeast, Schizosaccharomyces Phylogenetically, S. japonicus is the furthest removed from other species of fission yeast. The basic characteristics of cell proliferation are shared among all fission yeast, including the process of binary fission during vegetative growth, conjugatio…
  • Position matters: multiple functions of LINC-dependent chromosome positioning during meiosis. [Journal Article]
    Curr Genet. 2017 Dec; 63(6):1037-1052.Katsumata K, Nishi E, … Yamamoto A
  • Chromosome positioning is crucial for multiple chromosomal events, including DNA replication, repair, and recombination. The linker of nucleoskeleton and cytoskeleton (LINC) complexes, which consist of conserved nuclear membrane proteins, were shown to control chromosome positioning and facilitate various biological processes by interacting with the cytoskeleton. However, the precise functions an…
  • Evidence for post-zygotic self-incompatibility in Handroanthus impetiginosus (Bignoniaceae). [Journal Article]
    Plant Reprod. 2017 06; 30(2):69-79.Bittencourt Júnior NS
  • Late-acting self-incompatibility (LSI) has been defined as a genetically controlled self-sterility mechanism that prevents seed set by selfing, despite normal pollen tube growth and ovule penetration in self-pollinated pistils. In species of the Bignoniaceae with LSI, such as Handroanthus impetiginosus, the selfed pistils are characterized by a marked delay in ovule penetration, fertilization, an…
  • m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. [Journal Article]
    Nature. 2016 12 08; 540(7632):301-304.Haussmann IU, Bodi Z, … Soller M
  • N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins. The mammalian mRNA m6A methylosome is a complex of nuclear proteins that includes METTL3 (methyltransferase-like 3), METTL14, WTAP (Wilms tumour 1-associated protein) and KIAA1429. Drosophila has corresponding homologues named Ime4 and KAR4 (Inducer of meiosi…
  • Molecular basis of Kar9-Bim1 complex function during mating and spindle positioning. [Journal Article]
    Mol Biol Cell. 2016 Sep 28 [Online ahead of print]Manatschal C, Farcas AM, … Steinmetz MO
  • The Kar9 pathway promotes nuclear fusion during mating and spindle alignment during metaphase in budding yeast. How Kar9 supports the different outcome of these two divergent processes is an open question. Here, we show that three sites in the C-terminal disordered domain of Kar9 mediate tight Kar9 interaction with the C-terminal dimerization domain of Bim1 (EB1 orthologue). Site1 and Site2 conta…
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