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Did you mean: (kava)?
(kava kava)
919 results
  • Monoamine Oxidase Inhibition by Kavalactones from Kava (Piper Methysticum). [Journal Article]
    Planta Med 2019Prinsloo D, van Dyk S, … Petzer JP
  • Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and neurodegenerative disorders. This study examined the MAO inhibition potential of kavain and other kavalactones from the roots of kava (Piper methysticum), a plant that has been used for its anxiolytic properties. (±)-Kavain was found to be a good po…
  • Identification of a Kavain Analog with Efficient Anti-inflammatory Effects. [Journal Article]
    Sci Rep 2019; 9(1):12940Huck O, Han X, … Amar S
  • Kavain, a compound derived from Piper methysticum, has demonstrated anti-inflammatory properties. To optimize its drug properties, identification and development of new kavain-derived compounds was undertaken. A focused library of analogs was synthesized and their effects on Porphyromonas gingivalis (P. gingivalis) elicited inflammation were evaluated in vitro and in vivo. The library contained c…
  • The biosynthetic origin of psychoactive kavalactones in kava. [Journal Article]
    Nat Plants 2019; 5(8):867-878Pluskal T, Torrens-Spence MP, … Weng JK
  • Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. However, an unknown biosynthetic machinery and…
  • The Effect of Bupivacaine on the Efficacy of Antibiotic Coating on Penile Implants in Preventing Infection. [Journal Article]
    Sex Med 2019; 7(3):337-344Lokeshwar SD, Horodyski L, … Ramasamy R
  • CONCLUSIONS: This suggests that the use of BUP does not affect the protective effects of antibiotic dips and can potentially be used during penile prosthesis surgery pending clinical trials.The addition of BUP does not impede the in vitro antibacterial activity of InhibiZone-coated AMS or R+G-soaked Coloplast. Whether these in vitro findings translate to surgical outcomes needs to be evaluated in future preclinical trials. Lokeshwar SD, Horodyski L, Lahorewala SS, et al. The Effect of Bupivacaine on the Efficacy of Antibiotic Coating on Penile Implants in Preventing Infection. J Sex Med 2019;7:337-344.
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