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19,948 results
  • Chronic administration of ketamine induces cognitive deterioration by restraining synaptic signaling. [Journal Article]
    Mol Psychiatry. 2020 Jun 02 [Online ahead of print]Luo Y, Yu Y, … Fan N
  • The discovery of the rapid antidepressant effects of ketamine has arguably been the most important advance in depression treatment. Recently, it was reported that repeated long-term ketamine administration is effective in preventing relapse of depression, which may broaden the clinical use of ketamine. However, long-term treatment with ketamine produces cognitive impairments, and the underlying m…
  • Cell-type specific modulation of NMDA receptors triggers antidepressant actions. [Journal Article]
    Mol Psychiatry. 2020 Jun 02 [Online ahead of print]Pothula S, Kato T, … Duman RS
  • Both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can exert rapid antidepressant effects as shown in several animal and human studies. However, how this bidirectional modulation of NMDARs causes similar antidepressant effects remains unknown. Notably, the initial cellular trigger, specific cell-type(s), and subunit(s) of NMDARs mediating the antidepressant-like e…
  • Ketamine as a mental health treatment: Are acute psychoactive effects associated with outcomes? A systematic review. [Review]
    Behav Brain Res. 2020 May 30 [Online ahead of print]Grabski M, Borissova A, … Curran HV
  • Esketamine was recently licensed by the US Food and Drug Administration (FDA) and European Drug Agency (EDA) for use in treatment resistant depression (TRD), and promising research indicates ketamine as a possible treatment in other mental health conditions. While the underlying mechanisms remain unclear, it has been hypothesised that acute psychoactive effects during ketamine administration may …
  • Adjuncts to local anesthetic wound infiltration for postoperative analgesia: a systematic review. [Review]
    Reg Anesth Pain Med. 2020 May 30 [Online ahead of print]Bai JW, An D, … Chan V
  • Local anesthetics (LAs) are commonly infiltrated into surgical wounds for postsurgical analgesia. While many adjuncts to LA agents have been studied, it is unclear which adjuncts are most effective for co-infiltration to improve and prolong analgesia. We performed a systematic review on adjuncts (excluding epinephrine) to local infiltrative anesthesia to determine their analgesic efficacy and opi…
  • A Systematic Review of Intra-articular Ketamine for Post-operative Analgesia. [Journal Article]
    Am J Phys Med Rehabil. 2020 May 26 [Online ahead of print]Covington SM, D'Souza RS, … Qu W
  • CONCLUSIONS: Patients who received IA ketamine generally reported lower pain scores and had lower post-operative opioid consumption after orthopedic joint procedures. This suggests that the IA route of ketamine delivery may be a useful analgesic modality, although future larger-scale trials should explore its pharmacokinetics, optimal dosing, safety and cost-effectiveness.
  • Astrocytes in rapid ketamine antidepressant action. [Review]
    Neuropharmacology. 2020 May 25; 173:108158.Stenovec M, Li B, … Zorec R
  • Ketamine, a general anaesthetic and psychotomimetic drug, exerts rapid, potent and long-lasting antidepressant effect, albeit the cellular and molecular mechanisms of this action are yet to be discovered. Besides targeting neuronal NMDARs fundamental for synaptic transmission, ketamine affects the function of astroglia the key homeostatic cells of the central nervous system that contribute to pat…
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