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(ketogenesis)
1,614 results
  • Sleep profile during fasting in PPAR-alpha knockout mice. [Journal Article]
    Physiol Behav 2019; :112760Kondo Y, Chikahisa S, … Séi H
  • Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family and plays an important role in regulating gene expression associated with lipid metabolism. PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy metabolism is known to affect sleep regulation, manipulations that change PPARα a…
  • M-channel activation contributes to the anticonvulsant action of the ketone body β-hydroxybutyrate. [Journal Article]
    J Pharmacol Exp Ther 2019Manville RW, Papanikolaou M, Abbott GW
  • Ketogenic diets are effective therapies for refractory epilepsy, yet the underlying mechanisms are incompletely understood. The anticonvulsant efficacy of ketogenic diets correlates positively to the serum concentration of β-hydroxybutyrate (BHB), the primary ketone body generated by ketosis. Voltage-gated potassium channels generated by KCNQ2-5 subunits, especially KCNQ2/3 heteromers, generate t…
  • Ketogenic diet activates protective γδ T cell responses against influenza virus infection. [Journal Article]
    Sci Immunol 2019; 4(41)Goldberg EL, Molony RD, … Iwasaki A
  • Influenza A virus (IAV) infection-associated morbidity and mortality are a key global health care concern, necessitating the identification of new therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of γδ…
  • History of dietary treatment from Wilder's hypothesis to the first open studies in the 1920s. [Review]
    Epilepsy Behav 2019; 101(Pt A):106588Höhn S, Dozières-Puyravel B, Auvin S
  • In the ketogenic diet (KD) history, Wilder is often mentioned as the first author to report on the use of KD for patients with epilepsy. Our article aimed to understand how Wilder formulated the hypothesis of the KD effectiveness for patients with epilepsy, and how the KD was used and spread in the 1920s. In 1921, Wilder published two articles on the effects of ketonemia on epilepsy. He first rep…
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