Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
1,086 results
  • Antimicrobial Resistance of Campylobacter in Broiler Chicken Along the Food Chain in Canada. [Journal Article]
    Foodborne Pathog Dis. 2020 Mar 04 [Online ahead of print]Dramé O, Leclair D, … Ravel A
  • Antimicrobial resistance (AMR) is a major public health threat worldwide. The main objective of this study was to compare AMR in Campylobacter from broiler chickens raised on Canadian farms and their products in different geographical regions of Canada. To do this, antimicrobial susceptibility results from isolates of Campylobacter recovered from a national microbiological baseline study conducte…
  • Emerging Treatment Options for Infections by Multidrug-Resistant Gram-Positive Microorganisms. [Review]
    Microorganisms. 2020 Jan 30; 8(2)Koulenti D, Xu E, … Lipman J
  • Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug resistance, leading to the persistence and spread of difficult-to-treat infections. Several current antibacterial agents active against Gram-positive b…
  • Recent Advances in the Development of Macrolide Antibiotics as Antimicrobial Agents. [Journal Article]
    Mini Rev Med Chem. 2020; 20(7):601-625.Qin Y, Ma S
  • The chemical modification of natural products has been a major method in the discovery and synthesis of new macrolide antibiotics (MA) to treat a variety of infectious diseases. However, a lot of MA obtained in the above methods are no longer effective, because the bacteria quickly develop their resistance to these new macrolides, which has become a great threat to successful treatment of infecti…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Macrolide Antibiotics [BOOK]
    . National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The macrolides are bacteriostatic antibiotics with a broad spectrum of activity against many gram-positive bacteria. Currently available macrolides are well tolerated, orally available and widely used to treat mild-to-moderate infections. Several macrolide antibiotics have been linked to liver injury. Five macrolide antibiotics are currently available for use in the United States: erythromycin, c…
  • Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics. [Journal Article]
    J Med Chem. 2019 Nov 07 [Online ahead of print]Fernandes P, Pereira D, … Bertrand D
  • This is a review of the macrolide and ketolide field focusing on differentiating the pharmacodynamics and especially the toxicology of the macrolides and ketolides. We emphasize the diversity in pharmacodynamics and toxicity of the macrolides and ketolides, resulting from even small structural changes, which makes it important to consider the various different compounds separately, not necessaril…
  • The effect of antibiotics on the composition of the intestinal microbiota - a systematic review. [Review]
    J Infect. 2019 12; 79(6):471-489.Zimmermann P, Curtis N
  • CONCLUSIONS: Antibiotics have profound and sometimes persisting effects on the intestinal microbiota, characterised by diminished abundance of beneficial commensals and increased abundance of potentially detrimental microorganisms. Understanding these effects will help tailor antibiotic treatment and the use of probiotics to minimise this 'collateral damage'.
  • Cytotoxic comparison of macrolide antibiotics and their chlorinated disinfection byproduct mixtures. [Journal Article]
    Ecotoxicol Environ Saf. 2019 Oct 30; 182:109415.Feng Y, Guo Q, Shao B
  • Erythromycin (ERY), azithromycin (AZI) and telithromycin (TEL) are widely-used macrolide antibiotics that are frequently detected in various water environments, including resource water and drinking water. In the performed chlorination disinfection process, at least 10, 20 and 200 new disinfection byproducts of ERY, AZI and TEL, respectively, were observed (the mixtures of the disinfection byprod…
  • [New antibiotics in infection treatment]. [Editorial]
    Pol Merkur Lekarski. 2018 Dec 28; 45(270):213-219.Płusa T
  • The introduction of new molecules with antimicrobial activity is an opportunity for modern antibiotic therapy in the era of rapidly growing resistance to antibiotics. Beta-lactamase-inhibiting antibiotics, cephalosporinases and carbapenemases represent a breakthrough in previous treatments for infections caused by resistant pathogens. Ceftazidime with avibactam and ceftolozane with tazobactam sho…
  • [New β‑lactam antibiotics and β‑lactamase inhibitors against multidrug-resistant Gram-negative bacteria]. [Review]
    Internist (Berl). 2018 Dec; 59(12):1335-1343.Mischnik A, Lübbert C, Mutters NT
  • CONCLUSIONS: Clinical data are still indifferent and come from heterogeneous patient collectives. Direct comparisons with established treatment strategies, such as the "last-resort use" of polymyxins are hardly possible. Cases of early development of resistance have already been described. Finally, the importance of toxicity and optimal dosing-in organ failure or organ replacement procedures such as dialysis-remain unclear.
  • Look and Outlook on Enzyme-Mediated Macrolide Resistance. [Review]
    Front Microbiol. 2018; 9:1942.Golkar T, Zieliński M, Berghuis AM
  • Since their discovery in the early 1950s, macrolide antibiotics have been used in both agriculture and medicine. Specifically, macrolides such as erythromycin and azithromycin have found use as substitutes for β-lactam antibiotics in patients with penicillin allergies. Given the extensive use of this class of antibiotics it is no surprise that resistance has spread among pathogenic bacteria. In t…
  • How Macrolide Antibiotics Work. [Review]
    Trends Biochem Sci. 2018 09; 43(9):668-684.Vázquez-Laslop N, Mankin AS
  • Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been viewed as 'tunnel plugs' that stop the synthesis of every protein. More recent evidence, however, demonstrates that macrolides selectively inhibit the translation of a subset of cellular proteins, and that their acti…
  • Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. [Journal Article]
    Bioorg Med Chem Lett. 2018 08 01; 28(14):2358-2363.Zhao ZH, Zhang XX, … Lei PS
  • A series of quinoylalkyl side chains was designed and synthesized, followed by introduction into ketolides by coupling with building block 6 or 32. The corresponding targets 7a-n, 33b, and 33e were tested for their in vitro activities against a series of macrolide-sensitive and macrolide-resistant pathogens. Some of them showed a similar antibacterial spectrum and comparable activity to telithrom…
New Search Next