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41 results
  • The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target. [Review]
    Life Sci 2019; 232:116592Goudarzi A
  • Acetoacetyl-CoA thiolase also known as acetyl-CoA acetyltransferase (ACAT) corresponds to two enzymes, one cytosolic (ACAT2) and one mitochondrial (ACAT1), which is thought to catalyse reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA during ketogenesis and ketolysis respectively. In addition to this activity, ACAT1 is also involved in isoleucine degradation pathway. Defici…
  • The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. [Review]
    Life Sci 2017; 183:110-115Zhang S, Xie C
  • Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and rate-determining step of ketolysis. The product of OXCT1 converts to acetyl-CoA and finally fed into the tricarboxylic acid cycle for oxidation and ATP production. However, li…
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