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40,640 results
  • Kinins in Glioblastoma Microenvironment. [Journal Article]
    Cancer Microenviron 2019Oliveira MN, Breznik B, … Lah TT
  • Tumour progression involves interactions among various cancer cell clones, including the cancer stem cell subpopulation and exogenous cellular components, termed cancer stromal cells. The latter include a plethora of tumour infiltrating immunocompetent cells, among which are also immuno-modulatory mesenchymal stem cells, which by vigorous migration to growing tumours and susequent transdifferenti…
  • Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice. [Journal Article]
    Front Aging Neurosci 2019; 11:168Toricelli M, Evangelista SR, … Buck HS
  • Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with inflammation and immunogenic responses in the central and peripheral systems by th…
  • Retinal proteome associated with bradykinin-induced edema. [Journal Article]
    Exp Eye Res 2019; 186:107744Murugesan N, Fickweiler W, … Feener EP
  • The plasma kallikrein-stimulated generation of bradykinin (BK) has been implicated in diabetic macular edema (DME). This study characterizes the effects of BK on the ultrastructure and proteome of the rat retina. The effects of intravitreal injection of BK on retinal thickness and vascular ultrastructure in Sprague Dawley rats were analyzed and compared with the effects of VEGF using spectral-dom…
  • The contact pathway and sepsis. [Review]
    Res Pract Thromb Haemost 2019; 3(3):331-339Raghunathan V, Zilberman-Rudenko J, … Shatzel JJ
  • The contact pathway factors XI (FXI) and XII (FXII) have been demonstrated to be largely dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis. A growing body of literature, however, suggests that the contact pathway contributes to the pathologic host response to certain infectious organisms that produces the often-fatal syndrome known as sepsis. The contact …
  • Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice. [Journal Article]
    Biochem Pharmacol 2019; 168:119-132Brusco I, Justino AB, … Oliveira SM
  • Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment. Previous studies have shown that kinins and their B1 and B2 receptors contribute to chronic painful conditions. Thus, we investigated the involvement of kinins and their B1 and B2 rece…
  • Malaria infection promotes a selective expression of kinin receptors in murine liver. [Journal Article]
    Malar J 2019; 18(1):213Ventura PDS, Carvalho CPF, … Gazarini ML
  • CONCLUSIONS: Thus, it was observed through in vivo studies that the vasodilation induced by plasma ACE inhibition increases mice mortality during P. chabaudi infection. Besides, it was also seen that the anti-malarial chloroquine causes changes in B1R expression in liver, even after days of parasite clearance. The differential expression of B1R and B2R in liver during malaria infection may have an important role in the disease pathophysiology and represents an issue for clinical treatments.
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