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40,982 results
  • Differential Expression of Kinin Receptors in Human Wet and Dry Age-Related Macular Degeneration Retinae. [Journal Article]
    Pharmaceuticals (Basel). 2020 Jun 24; 13(6)Othman R, Berbari S, … Couture R
  • Kinins are vasoactive peptides and mediators of inflammation, which signal through two G protein-coupled receptors, B1 and B2 receptors (B1R, B2R). Recent pre-clinical findings suggest a primary role for B1R in a rat model of wet age-related macular degeneration (AMD). The aim of the present study was to investigate whether kinin receptors are differentially expressed in human wet and dry AMD ret…
  • High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease. [Journal Article]
    J Thromb Haemost. 2020 Jun 23 [Online ahead of print]Sparkenbaugh EM, Kasztan M, … Pawlinski R
  • CONCLUSIONS: We found elevated plasma levels of cleaved HK in sickle patients compared to healthy controls, suggesting ongoing HK activation in SCD. We used bone marrow transplantation to generate wild type and sickle cell mice on a HK-deficient background. We found that short-term HK deficiency attenuated thrombin generation and inflammation in sickle mice at steady state, which was independent of bradykinin signaling. Moreover, long-term HK deficiency attenuates kidney injury, reduces chronic inflammation, and ultimately improves of sickle mice.
  • Inhibition of metalloproteinases in therapy for severe lung injury due to COVID-19. [Review]
    Med Drug Discov. 2020 Sep; 7:100052.Solun B, Shoenfeld Y
  • Since its first appearance in December 2019 in the Chinese province of Wuhan, COVID-19 has spread rapidly throughout the world and poses a serious threat to public health. Acute respiratory failure due to widespread lung inflammation progress to acute respiratory distress syndrome (ARDS) with an altered pulmonary and alveolar function that can lead to disability, prolong hospitalizations, and adv…
  • Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios: Is Bradykinin Sneaking out of Our Sight? [Journal Article]
    Iran J Allergy Asthma Immunol. 2020 May 17; 19(S1):13-17.Ghahestani SM, Mahmoudi J, … Mostafaei H
  • The new virus SARS-CoV-2 is savagely spreading out over the world. The biologic studies show that the target receptor for the virus might be angiotensin-converting enzyme 2 (ACE2). This peptide is responsible for converting angiotensin II (Ang II), which is a profoundly active peptide, into Ang 1-7 with quite a balancing barbell function. It is emphasized that the direct target of the virus is AC…
  • Salivary gland transcriptome of the Asiatic Triatoma rubrofasciata. [Journal Article]
    Acta Trop. 2020 Jun 04 [Online ahead of print]Mizushima D, Tabbabi A, … Kato H
  • Salivary gland transcriptome analysis of the Asiatic Triatoma rubrofasciata was performed by high-throughput RNA sequencing. This analysis showed that the majority of reads accounting for 85.38% FPKM were mapped with a secreted class. Of these, the most abundant subclass accounting for 89.27% FPKM was the lipocalin family. In the lipocalin family, the most dominant molecules making up 70.49% FPKM…
  • A lesson from a saboteur: high molecular weight kininogen (HMWK) impact in COVID-19. [Review]
    Br J Pharmacol. 2020 Jun 04 [Online ahead of print]Colarusso C, Terlizzi M, … Sorrentino R
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified coronavirus which has spread from China to the rest of the world causing the pandemic coronavirus disease 19 (COVID-19). It has fatality rate that floats from 5 to 15% and the symptoms are fever, cough, myalgia and/or fatigue up to dyspnea, responsible for hospitalization and in most of the cases of artificial oxyg…
  • Heparin Blocks the Inhibition of Tissue Kallikrein 1 by Kallistatin through Electrostatic Repulsion. [Journal Article]
    Biomolecules. 2020 May 28; 10(6)Ma L, Wu J, … Zhou A
  • Kallistatin, also known as SERPINA4, has been implicated in the regulation of blood pressure and angiogenesis, due to its specific inhibition of tissue kallikrein 1 (KLK1) and/or by its heparin binding ability. The binding of heparin on kallistatin has been shown to block the inhibition of KLK1 by kallistatin but the detailed molecular mechanism underlying this blockade is unclear. Here we solved…
  • Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke. [Journal Article]
    Hamostaseologie. 2020 Jun; 40(2):153-164.Burkard P, Vögtle T, Nieswandt B
  • Platelets are anucleate cells known for their essential function in hemostasis and formation of thrombi under pathologic conditions. In recent years, strong evidence emerged demonstrating the critical involvement of platelets in inflammatory processes including acute ischemic stroke (AIS), which is one of the leading causes of death and disability worldwide. Recanalization of the occluded brain a…
  • Transcriptome data on salivary lipocalin family of the Asiatic Triatoma rubrofasciata. [Journal Article]
    Data Brief. 2020 Jun; 30:105647.Mizushima D, Tabbabi A, … Kato H
  • The dataset in this report is related to the research article entitled: "Salivary gland transcriptome of the Asiatic Triatoma rubrofasciata" [1]. Lipocalin family proteins were identified as the dominant component in T. rubrofasciata saliva, and phylogenetic analysis of the salivary lipocalins resulted in the formation of five major clades (clade I-V). For further characterization, each clade of …
  • A Role of Inflammation and Immunity in Essential Hypertension-Modeled and Analyzed Using Petri Nets. [Journal Article]
    Int J Mol Sci. 2020 May 09; 21(9)Formanowicz D, Rybarczyk A, … Formanowicz P
  • Recent studies have shown that the innate and adaptive immune system, together with low-grade inflammation, may play an important role in essential hypertension. In this work, to verify the importance of selected factors for the development of essential hypertension, we created a Petri net-based model and analyzed it. The analysis was based mainly on t-invariants, knockouts of selected fragments …
  • Role of Factor XIa and Plasma Kallikrein in Arterial and Venous Thrombosis. [Journal Article]
    Thromb Haemost. 2020 Jun; 120(6):883-993.Visser M, Heitmeier S, … Spronk HMH
  • Cardiovascular disease, including stroke, myocardial infarction, and venous thromboembolism, is one of the leading causes of morbidity and mortality worldwide. Excessive coagulation may cause vascular occlusion in arteries and veins eventually leading to thrombotic diseases. Studies in recent years suggest that coagulation factors are involved in these pathological mechanisms. Factors XIa (FXIa),…
  • A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications. [Journal Article]
    FASEB J. 2020 May 02 [Online ahead of print]Roche JA, Roche R
  • As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective pharmacotherapeutic strategies are rapidly explored to improve survival. In this paper, we use established and emerging …
  • The kallikrein-kinin pathway as a mechanism for auto-control of brown adipose tissue activity. [Journal Article]
    Nat Commun. 2020 May 01; 11(1):2132.Peyrou M, Cereijo R, … Villarroya F
  • Brown adipose tissue (BAT) is known to secrete regulatory factors in response to thermogenic stimuli. Components of the BAT secretome may exert local effects that contribute to BAT recruitment and activation. Here, we found that a thermogenic stimulus leads to enhanced secretion of kininogen (Kng) by BAT, owing to induction of kininogen 2 (Kng2) gene expression. Noradrenergic, cAMP-mediated signa…
  • Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome. [Journal Article]
    Elife. 2020 04 27; 9van de Veerdonk FL, Netea MG, … van der Hoeven H
  • COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the B1R. Without ACE2 acting as a guardian to …
  • B1 and B2 kinin receptor blockade improves psoriasis-like disease. [Journal Article]
    Br J Pharmacol. 2020 Apr 25 [Online ahead of print]Soley BDS, Silva LM, … Cabrini DA
  • CONCLUSIONS: Kinins exerted critical roles in imiquimod-induced psoriasis. Both B1 and B2 kinin receptors exacerbated the disease, influencing keratinocyte proliferation and immunopathology. Antagonists of one or even both kinin receptors might constitute a new strategy for the clinical treatment of psoriasis.
  • Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice. [Journal Article]
    Clin Sci (Lond). 2020 May 15; 134(9):1049-1061.Moran CS, Seto SW, … Golledge J
  • Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflammation and excessive matrix remodelling are considered important in AAA pathogenesis. Kinins are bioactive peptides important in regulating inflammation. Stimulation of the kinin B2 receptor has been previously reported to promote AAA development and rupture in a mouse model. The endogenous B2 recept…
  • Daytime changes of salivary biomarkers involved in pain. [Journal Article]
    J Oral Rehabil. 2020 Apr 11 [Online ahead of print]Jasim H, Ghafouri B, … Ernberg M
  • The study aimed to investigate salivary levels of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), substance P (SP) and glutamate at five time points from morning to afternoon in a well-characterised healthy and pain-free individuals. Ten young adults were included. Unstimulated and stimulated whole saliva were collected from each participant repeatedly across the day. Blood s…
  • [Hereditary angioedema due to C1-esterase inhibitor deficiency : novel approaches]. [Review]
    Rev Med Suisse. 2020 Apr 08; 16(689):675-678.Stehlin F, Ribi C
  • Hereditary angioedema type 1 and 2 are due to a deficiency in C1--esterase inhibitor. This molecule inhibits the generation of bradykinin, a potent inflammatory mediator that increases vascular permeability. Upon accumulation of bradykinin, patients affected develop painful subcutaneous or submucosal edemas that last for several days. In case the upper airways are affected, there is risk of suffo…
  • Kinin B1 Receptor Signaling in Skin Homeostasis and Wound Healing. [Review]
    Yale J Biol Med. 2020 Mar; 93(1):175-185.Matus CE, Bhoola KD, Figueroa CD
  • Kinins are proinflammatory peptides that are formed in the skin by the enzymatic action of tissue kallikrein (KLK1) on kininogens. Tissue kallikrein is produced by eccrine sweat glands and also by cells of the stratum granulosum and other skin appendages. Kinin formation may be favored during inflammatory skin disorders when plasma constituents, including kininogens, extravasate from venules and …
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