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172,882 results
  • Photon-counting cine-cardiac CT in the mouse. [Journal Article]
    PLoS One 2019; 14(9):e0218417Clark DP, Holbrook M, … Badea CT
  • The maturation of photon-counting detector (PCD) technology promises to enhance routine CT imaging applications with high-fidelity spectral information. In this paper, we demonstrate the power of this synergy and our complementary reconstruction techniques, performing 4D, cardiac PCD-CT data acquisition and reconstruction in a mouse model of atherosclerosis, including calcified plaque. Specifical…
  • Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome. [Journal Article]
    FASEB J 2019; :fj201901184RRSchädeli D, Serricchio M, … Bütikofer P
  • The mitochondrial signature glycerophospholipid, cardiolipin (CL), binds to transporters of the inner mitochondrial membrane and plays a central role in formation and stability of respiratory supercomplexes. Functional and structural requirement of CL for mitochondrial membrane proteins has been studied in vitro using purified reconstituted proteins or in CL synthesis knockout cells that are viab…
  • FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice. [Journal Article]
    Biomed Res Int 2019; 2019:3514574Zhang R, Wang T, … Liu F
  • The immune system is involved in the development of diabetes complications and IgG Fc gamma receptors (FcgRs) are key immune receptors responsible for the effective control of both humoral and innate immunity. We investigated the effects of members of the FcgR superfamily into both the streptozotocin plus high fat-induced type 2 diabetes and high fat diet (HFD) models. FcgRIII-/- diabetic mice an…
  • Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. [Journal Article]
    JCI Insight 2019; 4(18)Li Q, Cui S, … Chen X
  • Hereditary renal cystic diseases are characterized by defects in primary cilia of renal tubular epithelial cells and abnormality of tubular epithelium, which ultimately result in the development of renal cysts. However, the mechanism leading from abnormality of the tubular epithelium to cystogenesis is not well understood. In this report, we demonstrate a critical role for Robo2 in regulating epi…
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