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168 results
  • StatPearls: Lichen Sclerosus [BOOK]
    StatPearls Publishing: Treasure Island (FL) Chamli Amal A Charles Nicolle Hospital Souissi Asmahane A Rabta Hospital BOOK
  • Lichen sclerosus (LS) is a chronic inflammatory disease. It was first described by Hallopeau in 1881. Since then, multiple names have been used to describe this condition such as leukoplakia, kraurosis vulvae, balanitis xerotica obliterans, and lichen sclerosis et atrophicus. In 1976, the International Society for the Study of Vulvovaginal Disease adopted the term of lichen sclerosus. LS is a muc…
  • EMAS clinical guide: vulvar lichen sclerosus in peri and postmenopausal women. [Practice Guideline]
    Maturitas 2013; 74(3):279-82Pérez-López FR, Ceausu I, … EMAS, Spanish Menopause society
  • CONCLUSIONS: The etiology of LS in peri and postmenopausal women is unknown, although autoimmune, genetic and infectious factors have been implicated. Definitive diagnosis of non-malignant disorders depends on the histology of biopsied tissue. LS associated with cellular atypia should be classified as intraepithelial neoplasia. Topical corticosteroids are the most effective treatment, although prolonged treatment may be associated with dermal atrophy. Topical calcineurin inhibitors, such as tacrolimus or pimecrolimus, may be a safe and effective alternative treatment without risk of corticosteroid-related vulvar atrophy since they do not affect collagen synthesis. LS recurrences are frequent, and can lead to significant physical discomfort and emotional distress that affect mood and sexual relationships. Anatomical changes may require surgical management.
  • Urothelial cells in smears from cervix uteri. [Journal Article]
    J Cytol 2012; 29(1):41-4Palaoro LA, Guerra F, … Rocher AE
  • CONCLUSIONS: The umbrella cells may be mistaken for dysplastic cells originating in low grade squamous intraepithelial lesions lesions (LSILs) due to their nuclear and cytoplasm sizes. Therefore, it is important to know the possibility of their appearance in the cervical smears, especially in post menopausal patients in order to avoid a false diagnosis of an intraepithelial lesion. It is unlikely that deeper cells of urothelium would be confused with high grade squamous intraepithelial lesion (HSIL) cells. However, their presence might be a reason of mistake in the diagnosis. TCM is an under-recognized metaplastic phenomenon of the cervix and vagina, which is a mimicker of high-grade squamous intraepithelial lesion. The differential characteristic between umbrella cells, cells from TCM and the deeper urothelial cells, and LSIL and HSIL are detailed in the present paper.
  • Lichen sclerosus. [Historical Article]
    J Am Acad Dermatol 1995; 32(3):393-416; quiz 417-8Meffert JJ, Davis BM, Grimwood RE
  • Lichen sclerosus, usually appearing in the dermatologic literature under the names of lichen sclerosus et atrophicus, balanitis xerotica obliterans, and kraurosis vulvae, is an inflammatory disease with a multifactorial origin. A past association of lichen sclerosus and genital squamous cell carcinoma is not as close as once thought. Once considered primarily a surgical problem, especially when t…
  • [Modern approach to classification of precancerous conditions and vulvar dystrophy]. [Journal Article]
    Med Pregl 1995; 48(11-12):399-404Djurdjević S, Segedi D, … Vejnović J
  • Precancerous conditions of vulva are diseases which can exceed into carcinomas and are called preblastomatoses. These are all sorts of various diseases: intraepithelial vulvar neoplasias, Paget's disease, precancerous circumscript melanosis, malignant melanoma of the first Clark level, verrucous type of leukoplakia, vulvar dystrophy with atypia, giant Buschke-Lowenstein's condyloma and chronic sk…
  • [Vulvar lichen sclerosus]. [Review]
    Contracept Fertil Sex 1993; 21(3):237-40Bazex J, Bayle-Lebey P
  • Lichen sclerosus's pathogeny, the most frequent vulvar dystrophy predominant at the start of menopause, is still enigmatic. Its repercussions on the functional level can be disabling. Its clinical sides include atrophy and sclerosis. The evolution of the past towards great atrophies (kraurosis vulvae) may today be prevented by early diagnosis and treatment (essentially dermocorticoïde). Even if t…
  • [Sex hormone level of malnourished vulvae treated with traditional Chinese medicine]. [Journal Article]
    Zhong Xi Yi Jie He Za Zhi 1990; 10(8):479-81, 453-4Wang YF
  • This paper intend to introduce the therapeutic method of combining TCM and WM as well as the laboratory study to 91 patients with malnourished vulvae. The results showed that the concentration of the luteinizing hormone (LH) in the patients' serum was evidently lower than that in the control group (P less than 0.01). The concentration of follicle-stimulating hormone (FSH) was evidently higher tha…
  • [Results of surgical treatment of vulvar cancer]. [Journal Article]
    Geburtshilfe Frauenheilkd 1990; 50(5):375-82Kreienberg R, Beck T, … Friedberg F
  • 129 patients with carcinoma of the vulva were treated at the Dept. of Obstetrics and Gynaecology from 1966-1985. FIGO stage I was observed in 21% of the cases, FIGO stage II in 50%, FIGO stage III in 10% and FIGO stage IV in 8% of the patients. In 10% of the patients, definite classification was not possible. Mean age at the onset of the disease was 66.2 years, the mean time of observation 63 mon…
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