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24,729 results
  • Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform. [Journal Article]
    PLoS Biol 2020; 18(1):e3000583Blatti C, Emad A, … Sinha S
  • We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis. The system specializes in "knowledge-guided" data mining and machine learning …
  • [Intersociety guidelines for diagnosis, treatment and prevention of Clostridioides difficile infections]. [Guideline]
    Medicina (B Aires) 2020; 80 Suppl 1:1-32Barcán L, Ducatenzeiler L, … Grupo de Trabajo Control de Infecciones
  • Clostridioides difficile infections (CDI) are among the leading causes of health care-associated infections. The epidemiology of CDI has undergone major changes in the last decade, showing an increase in incidence, severity, and rate of relapse. These guidelines were developed by specialists from four scientific societies: Sociedad Argentina de Infectología (SADI), Sociedad Argentina de Gastroent…
  • [Therapeutic innovations for hemophilia]. [Journal Article]
    Rev Med Suisse 2020; 16(676-7):47-52Hermans C, Lambert C
  • The current treatment of haemophilia relies on intravenous administration several times a week of clotting factors VIII (FVIII) or IX (FIX) concentrates, either derived from plasma or produced by biotechnology. This preventive treatment is burdensome, expensive and associated with the risk of developing neutralizing antibodies (inhibitors). Factor VIII and IX concentrates with a longer half-life,…
  • The pace of modern culture. [Journal Article]
    Nat Hum Behav 2020Lambert B, Kontonatsios G, … Leroi AM
  • Here we investigate the evolutionary dynamics of several kinds of modern cultural artefacts-pop music, novels, the clinical literature and cars-as well as a collection of organic populations. In contrast to the general belief that modern culture evolves very quickly, we show that rates of modern cultural evolution are comparable to those of many animal populations. Using time-series methods, we s…
  • Antarctic Ice Sheet and emission scenario controls on 21st-century extreme sea-level changes. [Journal Article]
    Nat Commun 2020; 11(1):390Frederikse T, Buchanan MK, … Wal RSWV
  • Uncertainties in Representative Concentration Pathway (RCP) scenarios and Antarctic Ice Sheet (AIS) melt propagate into uncertainties in projected mean sea-level (MSL) changes and extreme sea-level (ESL) events. Here we quantify the impact of RCP scenarios and AIS contributions on 21st-century ESL changes at tide-gauge sites across the globe using extreme-value statistics. We find that even under…
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