- Vocal Fold "Paralysis": An Early Sign in Multiple System Atrophy. [Journal Article]
- JVJ Voice 2019 Jul 16
- Multiple system atrophy (MSA) is a neurodegenerative disease characterized by a cerebellar syndrome, autonomic dysfunction, and extrapyramidal signs. Extrapyramidal signs may manifest as parkinsonism…
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by a cerebellar syndrome, autonomic dysfunction, and extrapyramidal signs. Extrapyramidal signs may manifest as parkinsonism as well as dystonia, which is the involuntary contraction of a muscle(s) resulting in an abnormal posture. MSA belongs to a family of diseases known as α-synucleinopathies which are associated with dream enactment reflecting REM sleep behavior disorder (RBD). In patients with MSA, dystonia or paresis may involve the laryngeal muscles resulting in vocal fold hypomobility. We identified four individuals presenting with vocal complaints and subsequently diagnosed with vocal fold "paralysis." Within one year, each patient developed neurologic symptoms and upon evaluation by a movement disorders specialist was diagnosed with probable MSA. Our findings highlight the importance of screening by otolaryngologists when patients are diagnosed with vocal fold hypomobility. Specifically, patients should be assessed for RBD by questioning others if he/she acts out their dreams. The presence of RBD raises clinical suspicion for a synucleinopathy such as MSA. Untreated patients with MSA experiencing nocturnal stridor and breathing disorders have an increased risk for sudden death. Therefore, early evaluation by a movement disorders specialist to promptly diagnose MSA may have a substantial effect on morbidity and mortality in this high-risk patient population.
- Risk factors of post-tonsillectomy dysgeusia. [Journal Article]
- ANAuris Nasus Larynx 2019 Jul 16
- CONCLUSIONS: Women and under 60 years old patients had a significantly higher rate of dysgeusia after tonsillectomy. It is recommended that patients are informed of the potential postoperative complication of dysgeusia.
- Neonatal resuscitation using a supraglottic airway device for improved mortality and morbidity outcomes in a low-income country: study protocol for a randomized trial. [Journal Article]
- TTrials 2019 Jul 19; 20(1):444
- CONCLUSIONS: Although indications for the beneficial effect of a supraglottic airway device in the context of neonatal resuscitation exist, so far no large studies powered to assess mortality and morbidity have been carried out. We hypothesize that effective ventilation will be easier to achieve with a supraglottic airway device than with a face mask, decreasing early neonatal mortality and brain injury from neonatal encephalopathy. The findings of this trial will be important for low and middle-resource settings where the majority of intrapartum-related events occur.
- Acute generalized exanthematous pustulosis induced by amoxicillin/clavulanic acid, manifesting as severe laryngeal edema. [Letter]
- JDJ Dermatol 2019 Jul 19
- "Teşrih-ül Ebdan ve Tercümânı Kıbale-i Feyles슩fan": the first illustrated anatomy handwritten textbook in Ottoman-Turkish medicine. [Journal Article]
- SRSurg Radiol Anat 2019 Jul 18
- CONCLUSIONS: While some of these illustrations are similar to the illustrations of the earlier authors such as Ahmed Ibn Mansur, Andreas Vesalius and Juan Valverde de Amusco, others are peculiar to this book. This book is highly significant for it's being the first Turkish book in the field of anatomy in Ottoman-Turkish medicine and the text's being supplemented by illustrations. This book is also a fundamental source for translation of anatomical terms into Turkish. Our knowledge of anatomy continues to improve thanks to the contributions of leading scientists such as Itâkî and, therefore, he deserves praise.
- NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents. [Journal Article]
- CHCancers Head Neck 2019; 4:3
- CONCLUSIONS: Genetic alterations in NSD1 hold potential as novel prognostic biomarkers in HPV(-) head and neck cancers. NSD1 mutations in HPV(+) cancers may also play a prognostic role, although this effect must be examined in a larger cohort. NSD1 downregulation results in improved sensitivity to cisplatin and carboplatin, but not to other DNA-damaging agents, in epithelial cells. Increased sensitivity to platinum-based chemotherapy agents associated with NSD1 depletion may contribute to improved survival in HPV(-) HNSCCs. Further studies are needed to determine mechanisms through which NSD1 protects HPV(-) HNSCC cells from platinum-based therapy, as well as confirmation of NSD1 effect in HPV(+) HNSCC.
- New Jurassic mammaliaform sheds light on early evolution of mammal-like hyoid bones. [Journal Article]
- SciScience 2019 Jul 19; 365(6450):276-279
- We report a new Jurassic docodontan mammaliaform found in China that is preserved with the hyoid bones. Its basihyal, ceratohyal, epihyal, and thyrohyal bones have mobile joints and are arranged in a…
We report a new Jurassic docodontan mammaliaform found in China that is preserved with the hyoid bones. Its basihyal, ceratohyal, epihyal, and thyrohyal bones have mobile joints and are arranged in a saddle-shaped configuration, as in the mobile linkage of the hyoid apparatus of extant mammals. These are fundamentally different from the simple hyoid rods of nonmammaliaform cynodonts, which were likely associated with a wide, nonmuscularized throat, as seen in extant reptiles. The hyoid apparatus provides a framework for the larynx and for the constricted, muscularized esophagus, crucial for transport and powered swallowing of the masticated food and liquid in extant mammals. These derived structural components of hyoids evolved among early diverging mammaliaforms, before the disconnection of the middle ear from the mandible in crown mammals.
- Surgical outcomes of myringoplasty using platelet-rich plasma and evaluation of the outcome-associated factors. [Journal Article]
- ANAuris Nasus Larynx 2019 Jul 15
- CONCLUSIONS: Minimally invasive myringoplasty using PRP has a satisfactory success rate even for large-sized tympanic membrane perforations. PRP is autologous and its use is non-toxic and safe. Although informed consent from the patient is necessary for the repetition of the surgery and for patients older than 80years, this technique appears to be a promising office-based procedure for closure of chronic tympanic membrane perforations.
- In silico investigation of sneezing in a full real human upper airway using computational fluid dynamics method. [Journal Article]
- CMComput Methods Programs Biomed 2019; 177:203-209
- CONCLUSIONS: We introduced a model simulating a normal sneezing for two cases using a healthy 30-year-old male person. We believe that the model should be applied for different persons and an atlas of data could be obtained from different cases. This may help the medical system to have more data about the sneezing process.
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- Auditory-Articulatory Neural Alignment between Listener and Speaker during Verbal Communication. [Journal Article]
- CCCereb Cortex 2019 Jul 18
- Whether auditory processing of speech relies on reference to the articulatory motor information of speaker remains elusive. Here, we addressed this issue under a two-brain framework. Functional magne…
Whether auditory processing of speech relies on reference to the articulatory motor information of speaker remains elusive. Here, we addressed this issue under a two-brain framework. Functional magnetic resonance imaging was applied to record the brain activities of speakers when telling real-life stories and later of listeners when listening to the audio recordings of these stories. Based on between-brain seed-to-voxel correlation analyses, we revealed that neural dynamics in listeners' auditory temporal cortex are temporally coupled with the dynamics in the speaker's larynx/phonation area. Moreover, the coupling response in listener's left auditory temporal cortex follows the hierarchical organization for speech processing, with response lags in A1+, STG/STS, and MTG increasing linearly. Further, listeners showing greater coupling responses understand the speech better. When comprehension fails, such interbrain auditory-articulation coupling vanishes substantially. These findings suggest that a listener's auditory system and a speaker's articulatory system are inherently aligned during naturalistic verbal interaction, and such alignment is associated with high-level information transfer from the speaker to the listener. Our study provides reliable evidence supporting that references to the articulatory motor information of speaker facilitate speech comprehension under a naturalistic scene.