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23,480 results
  • Uterineintravenous leiomyomatosis with cardiac involvement. [Case Reports]
    Radiol Case Rep. 2020 Aug; 15(8):1389-1393.Masood I, Duran C, … Frank L
  • Intravenous leiomyomatosis is a histologically benign smooth muscle tumor that arises either by direct extension of a uterine leiomyoma into the adjacent veins or by vascular intimal smooth muscle proliferation. Herein, we report the case of a 60-year-old female who was noted to have suspected cardiac mass on elective echocardiography done electively for abnormal electrocardiographic findings. Co…
  • The usefulness of periostin determination in gynecology and obstetrics. [Journal Article]
    Ginekol Pol. 2020; 91(6):364-351.Kobierzycki C, Latkowski KJ, Dziegiel P
  • Periostin (POSTN) is a multifunctional glycoprotein that belongs to the group of extracellular matrix (ECM) proteins. Due to the molecular structure, cellular interactions, tissue locations as well functions of POSTN, we realize that its pivotal role is organization and regulation of ECM microenvironment. In available databases there is a lack of data summarizing current knowledge about POSTN exp…
  • Educational Case: Smooth Muscle Tumors of the Uterus. [Journal Article]
    Acad Pathol. 2020 Jan-Dec; 7:2374289520932285.Brioso Rubio X, Beal SG, … Kresak J
  • The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objective…
  • [Clinicopathological features and gene phenotypes of benign metastasizing leiomyoma]. [Journal Article]
    Zhonghua Bing Li Xue Za Zhi. 2020 Jul 08; 49(7):704-709.Hu SS, Wang LL, … Wang JG
  • Objective: To study the clinicopathological features, immunophenotypes and MED12 gene status in benign metastasizing leiomyoma (BML). Methods: Nine cases of BML diagnosed at the Affiliated Hospital of Qingdao University from 2012 to 2018 were collected, and the radiologic and histologic features were analyzed. The protein expression of leiomyosarcoma-related driver genes, including RB1, PTEN,AT…
  • Human myoma tissue-based extracellular matrix models for testing the effects of irradiation on the HPV positive cells. [Journal Article]
    Virol J. 2020 Jun 30; 17(1):87.Tuominen H, Al-Samadi A, … Rautava J
  • CONCLUSIONS: Both solid and gelatinous human leiomyoma-based extracellular matrix models were suitable platforms to study the invasion of HPV positive cervical carcinoma cells in vitro. SiHa cells with less HPV copy number cells invaded slightly better and were slightly more sensitive to irradiation than CaSki cells with high HPV copy number. However, there was no drastic differences between the invasion properties of these carcinoma cells.
  • 90 YEARS OF PROGESTERONE: Selective progesterone receptor modulators in gynaecological therapies. [Journal Article]
    J Mol Endocrinol. 2020 Jul; 65(1):T15-T33.Critchley HOD, Chodankar RR
  • Abnormal uterine bleeding (AUB) is a chronic, debilitating and common condition affecting one in four women of reproductive age. Current treatments (conservative, medical and surgical) may be unsuitable, poorly tolerated or may result in loss of fertility. Selective progesterone receptor modulators (SPRMs) influence progesterone-regulated pathways, a hormone critical to female reproductive health…
  • Intraplacental Leiomyoma in a Case of Second-Trimester Intrauterine Fetal Demise. [Case Reports]
    Clin Pathol. 2020 Jan-Dec; 13:2632010X20928328.Koo SC, Bu F
  • Intraplacental leiomyomas are extremely rare and are generally incidental findings in term placentas. We present the first reported case of a placental leiomyoma associated with preterm intrauterine fetal demise, with histological findings providing the cause of adverse outcome. This was an intrauterine fetal demise detected at 26 weeks gestation with a placental finding of a 2.8-cm leiomyoma. Hi…
  • Nonpuerperal Uterine Inversion: What the Gynaecologists Need to Know? [Review]
    Obstet Gynecol Int. 2020; 2020:8625186.Herath RP, Patabendige M, … Wijesinghe PS
  • CONCLUSIONS: Fibroids were the commonest cause for NPUI. Malignancies accounted for one-third of cases. A combined abdominal and vaginal approach, followed by hysterectomy or repair after repositioning, seems to be better for nonmalignant cases.
  • Granular necrosis: a distinctive form of cell death in malignant tumours. [Review]
    Pathology. 2020 Jun 16 [Online ahead of print]Samaratunga H, Delahunt B, … Egevad L
  • Foci of necrosis are frequently seen in malignant tumours and may be due to a variety of causes. Different types of necrosis are given various names based upon their morphological features and presumed pathogenesis, such as coagulative, liquefactive and fibrinoid necrosis. Here, we propose the term 'granular necrosis' (GN) for a specific form of tumour necrosis characterised by the presence of we…
  • Dietary Fat Intake and Risk of Uterine Leiomyomata: A Prospective Ultrasound Study. [Journal Article]
    Am J Epidemiol. 2020 Jun 17 [Online ahead of print]Brasky TM, Bethea TN, … Wise LA
  • Uterine leiomyomata (UL) are associated with severe reproductive morbidity and are the primary indication for hysterectomy in the United States. A recent prospective cohort study of Black women reported positive associations between intakes of marine-sourced omega-3 fatty acids and UL risk. We examined whether intakes of dietary fat were associated with UL incidence in a 5-year prospective study …
  • [Clinical analysis of intravenous-cardiac leiomyomatosis]. [Journal Article]
    Zhonghua Yi Xue Za Zhi. 2020 Jun 09; 100(22):1741-1744.Zhao Y, Huang ZH, … Dong R
  • CONCLUSIONS: Patients with intravenous-cardiac leiomyomatosis are lack of specific manifestations. Early diagnosis is crucial for the treatment of this disease. Tumor resection is an effective treatment, which can improve the quality of life and long-term survival of patients.
  • Pigment epithelium derived factor as a novel multi-target treatment for uterine fibroids. [Journal Article]
    Reprod Biomed Online. 2020 Apr 29 [Online ahead of print]Bar-Joseph H, Hikri E, … Shalgi R
  • CONCLUSIONS: This study suggests that recombinant PEDF is a putative novel potent physiological treatment for uterine fibroids. It targets several cornerstones of fibroid pathobiology in parallel, including vascular endothelial growth factor and oestrogen receptors, which are needed for vascularization, and restricts fibroid growth and final size in an animal model.
  • Nipple Ultrasound: A Pictorial Essay. [Review]
    Korean J Radiol. 2020 May 29 [Online ahead of print]Chiorean A, Pintican RM, … Duma M
  • Ultrasound (US) is an attractive diagnostic approach to identify both common and uncommon nipple pathologies, such as duct ectasia, nipple abscess, nipple leiomyoma, nipple adenoma, fibroepithelial polyp, ductal carcinoma in situ (restricted to nipple), invasive carcinoma, and Paget's disease. US is the reliable first-line imaging technique to assess nipple pathologies. It is useful to identify a…
  • Combination of MCM2 With Ki67 and p16 Immunohistochemistry Can Distinguish Uterine Leiomyosarcomas. [Journal Article]
    Int J Gynecol Pathol. 2020 Jul; 39(4):354-361.Keyhanian K, Lage JM, … Islam S
  • Our objective was to evaluate the diagnostic utility of 2 new proliferation markers, cyclin D1 and minichromosome maintenance complex component 2 (MCM2), in comparison with p16, p53, and Ki67 in differentiating the spectrum of smooth muscle tumors. An institutional database search from 2009 to 2017 identified 10 cases of uterine leiomyoma with bizarre nuclei (LBN), 12 smooth muscle tumors of unce…
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