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4,273 results
  • [Management of multiple myeloma in the relapsed/refractory patient]. [Journal Article]
    Rinsho Ketsueki 2019; 60(9):1257-1264Tabayashi T
  • The introduction of proteasome inhibitors (PIs), such as bortezomib (BTZ), and immunomodulatory drugs (IMiDs), including thalidomide (THAL) and lenalidomide (LEN), as first-line therapies in multiple myeloma (MM) has markedly improved the clinical outcomes of patients. However, MM remains incurable, and most patients eventually relapse. Moreover, prognosis is poor in patients who exhibit resistan…
  • New developments in the treatment of follicular lymphoma. [Journal Article]
    Rinsho Ketsueki 2019; 60(9):1199-1204Leonard JP
  • The treatment of follicular lymphoma (FL) continues to evolve. Those patients who present with minimal symptoms often are observed without therapy until significant progression occurs. When treatment is needed, initial options include single agent rituximab (R, anti-CD20), or various forms of chemoimmunotherapy including either R or the newer anti-CD20 monoclonal antibody obinutuzumab (O), with o…
  • [Cereblon as a primary target of IMiDs]. [Journal Article]
    Rinsho Ketsueki 2019; 60(9):1013-1019Ito T, Handa H
  • Various derivatives of thalidomide, a drug that is well-known for its teratogenicity, have recently been developed; among them, lenalidomide and pomalidomide, known as immunomodulatory drugs (IMiDs), have potent anticancer activity. These drugs have been approved by Food and Drug Administration for the treatment of several diseases, including multiple myeloma, under strict control. The primary di…
  • Advances in understanding the pathogenesis of graft-versus-host disease. [Review]
    Br J Haematol 2019Zeiser R
  • Acute graft-versus-host disease (GVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT). The emergence of different immuno-prophylaxis strategies, such as post-transplant cyclophosphamide or anti-thymocyteglobulin has reduced the incidence of acute GVHD in recent years. The biology of the acute GVHD we observe in the clinic may change due to the u…
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