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116,265 results
  • The recent advances in non-homologous end-joining through the lens of lymphocyte development. [Journal Article]
    DNA Repair (Amst). 2020 Jun 25; 94:102874.Wang XS, Lee BJ, Zha S
  • Lymphocyte development requires ordered assembly and subsequent modifications of the antigen receptor genes through V(D)J recombination and Immunoglobulin class switch recombination (CSR), respectively. While the programmed DNA cleavage events are initiated by lymphocyte-specific factors, the resulting DNA double-strand break (DSB) intermediates activate the ATM kinase-mediated DNA damage respons…
  • TH17/Treg imbalance and IL-17A increase after severe aneurysmal subarachnoid hemorrhage. [Journal Article]
    J Neuroimmunol. 2020 Jun 27; 346:577310.Moraes L, Trias N, … Grille S
  • To evaluate cerebrospinal fluid (CSF) and peripheral blood (PB) Treg, TH17 cells, TH1, TH2 and related cytokines in the acute phase of aSAH we assessed TH17, TH1, TH2, T regulatory cells and neutrophils in 39 aneurysmal subarachnoid hemorrhage (aSAH) patients and 56 controls. PB TH17 cells and TH17/Treg ratio were higher in CSF and PB of aSAH patients. Serum and CSF IL-17A levels were increased i…
  • Characterization of an i.p. D-galactose-induced cataract model in rats. [Journal Article]
    J Pharmacol Toxicol Methods. 2020 Jul 02 [Online ahead of print]Zhong L, Wang T, … Ling S
  • Cataracts have been identified as a main cause of global visual impairment and blindness; in addition, diabetic and aging cataracts are the most common types. The aim of this project was to develop a suitable animal model and investigate the key points of the mechanisms by which intraperitoneal (i.p.) injection of D-galactose forms cataracts. We optimized a method to investigate the safest and ef…
  • [Development of a New-type Nail-fold Microcirculation Imaging Device]. [Journal Article]
    Zhongguo Yi Liao Qi Xie Za Zhi. 2020 Mar 08; 44(3):216-220.Xie W, Chen D, … Zhuang C
  • At present, there are many problems in the nail-fold microcirculation detection devices, such as huge structure, inconvenience to carry. In addition, due to the patient's body shaking, the video is difficult to keep stable in collecting with the device, which brings great difficulties to the doctor's observation. We develop a small image acquisition device for nail-fold microcirculation based on …
  • The musings of a family therapist in Asia when COVID-19 struck. [Journal Article]
    Fam Process. 2020 Jul 03 [Online ahead of print]Lee WY
  • In response to the COVID-19 crisis in Asia, a family therapist in Hong Kong shares her experiences and reflections, both personally and professionally from an Eastern lens. From a state of shock and immobilization to moments of contemplation, she highlights her struggle with being caught between her Eastern roots and Western training, which has become more salient in facing COVID-19. While the la…
  • Recent developments in regenerative ophthalmology. [Review]
    Sci China Life Sci. 2020 Jul 02 [Online ahead of print]Shen Y, Shen H, … Dai J
  • Regenerative medicine (RM) is one of the most promising disciplines for advancements in modern medicine, and regenerative ophthalmology (RO) is one of the most active fields of regenerative medicine. This review aims to provide an overview of regenerative ophthalmology, including the range of tools and materials being used, and to describe its application in ophthalmologic subspecialties, with th…
  • Laryngopharyngeal reflux image quantization and analysis of its severity. [Journal Article]
    Sci Rep. 2020 Jul 03; 10(1):10975.Kuo CJ, Kao CH, … Liu SC
  • Laryngopharyngeal reflux (LPR) is a prevalent disease affecting a high proportion of patients seeking laryngology consultation. Diagnosis is made subjectively based on history, symptoms, and endoscopic assessment. The results depend on the examiner's interpretation of endoscopic images. There are still no consistent objective diagnostic methods. The aim of this study is to use image processing te…
  • Inferring evolutionary dynamics of mutation rates through the lens of mutation spectrum variation. [Review]
    Curr Opin Genet Dev. 2020 Jun 30; 62:50-57.Carlson J, DeWitt WS, Harris K
  • There are many possible failure points in the transmission of genetic information that can produce heritable germline mutations. Once a mutation has been passed from parents to offspring for several generations, it can be difficult or impossible to identify its root cause; however, sometimes the nature of the ancestral and derived DNA sequences can provide mechanistic clues about a genetic change…
  • For the AAO "The IOL Issue" Intraocular Lenses: Overview of Designs, Materials, and Pathophysiology. [Journal Article]
    Ophthalmology. 2020 Jun 30 [Online ahead of print]Werner L
  • The aim of this article was to provide an overview of intraocular lenses (IOLs) currently used in cataract surgery. Aspects presented included design features related to IOL construction and sites of fixation, optic, filter, and haptic materials, as well as the pathophysiology of uveal biocompatibility, capsular biocompatibility, and postoperative IOL opacification. This overview also includes su…
  • Visian Implantable Collamer Lens Behavior in Descemet Membrane Endothelial Keratoplasty Surgery. [Journal Article]
    Cornea. 2020 Jun 30 [Online ahead of print]Alió Del Barrio JL, DʼOria F, Alió JL
  • Endothelial damage is one of the leading causes for anterior chamber phakic intraocular lens (AC-pIOL) explantation. In young patients, where the pIOL is explanted alone without lensectomy, an important anisometropia is left, unless an exchange with a posterior chamber (PC) pIOL is performed. However, in the event of corneal decompensation, there is no published evidence about the potential influ…
  • Regional comparison of preoperative biometry for cataract surgery between two domestic institutions. [Journal Article]
    Int Ophthalmol. 2020 Jul 02 [Online ahead of print]Kamiya K, Fujimura F, … Miyata K
  • CONCLUSIONS: There were significant differences in the mean keratometric readings, the anterior chamber depth, the axial length, and the lens thickness, by approximately 0.3 D, 0.3 mm, 0.6 mm, and 0.3 mm, respectively. Regional variations of the preoperative biometry did exist to some extent, and were not clinically negligible, in consideration of the precise IOL power calculation and the subsequent refractive accuracy of cataract surgery.
  • Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework. [Review]
    mBio. 2020 Jul 02; 11(4)Pirofski LA, Casadevall A
  • The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the "damage-response fram…
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