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831,205 results
  • DOCK-family proteins: key players in immune surveillance mechanisms. [Journal Article]
    Int Immunol 2019Kunimura K, Uruno T, Fukui Y
  • Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK-family proteins do not contain the Dbl homology domain typically found in other GEFs, they mediate the GTP-GDP exchange reaction through the DHR-2 domain. In mammals, this family consists of 11 members, each of which has u…
  • Role of Neutrophils in Ischemic Heart Failure. [Journal Article]
    Pharmacol Ther 2019; :107424Kain V, Halade GV
  • Amplified innate leukocytes (neutrophils and monocytes/macrophages) are associated with advanced ischemic and non-ischemic heart failure (HF). Intensified neutrophilic leukocytosis (neutrophilia) and sustained activation of neutrophils is the predominant factor that determines over activated inflammation in acute HF and the outcome of long-term chronic HF. After heart attack, the first wave of in…
  • Chemokine CXCb1 stimulates formation of NETs in trunk kidney neutrophils of common carp. [Journal Article]
    Dev Comp Immunol 2019; :103521Pijanowski L, Kemenade BMLV, Chadzinska M
  • Both in mammals and in fish, CXC chemokines activate leukocytes and regulate their migration both under normal physiological and inflammatory conditions. Moreover, in mammalian neutrophils CXC chemokines also stimulate the formation of neutrophil extracellular traps (NETs). Here, we investigated the effects of recombinant carp CXCL8s and CXCb1 on NET formation in neutrophils from the head (HK) an…
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