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3,359 results
  • Intracrinology-revisited and prostate cancer. [Review]
    J Steroid Biochem Mol Biol 2019; :105499Penning TM, Detlefsen A
  • The formation of steroid hormones in peripheral target tissues is referred to as their intracrine formation. This process occurs in hormone dependent malignancies such as prostate and breast cancer in which the disease can be either castrate resistant or occur post-menopausally, respectively. In these instances, the major precursor steroid of androgens and estrogens is dehydroepiandrosterone (DHE…
  • Fertility Preservation Outcomes in Adolescent and Young Adult Feminizing Transgender Patients. [Journal Article]
    Pediatrics 2019; 144(3)Barnard EP, Dhar CP, … Valli-Pulaski H
  • CONCLUSIONS: Semen cryopreservation is a viable method of fertility preservation in adolescent and young adult transgender individuals and can be considered in patients who have already initiated therapy for gender dysphoria. Further research is needed to determine the optimal length of time these therapies should be discontinued to facilitate successful semen cryopreservation.
  • GnRHa Before Single-Port Laparoscopic Hysterectomy in a Large Barrel-Shaped Uterus. [Journal Article]
    JSLS 2019 Jul-Sep; 23(3)Torng PL, Pan SP, … Hwang JS
  • CONCLUSIONS: GnRHa pretreatment in patients with a large barrel-shaped uterus during SPH is feasible with shortened operative time. However, the higher complication rates in these patients suggest that a weight-reduced barrel-shaped uterus that is achieved with GnRHa treatment could still be difficult and should be handled in cautious.
  • Development of Level A in vitro-in vivo correlations for peptide loaded PLGA microspheres. [Journal Article]
    J Control Release 2019; 308:1-13Andhariya JV, Jog R, … Burgess DJ
  • Peptide loaded PLGA microsphere products are more complex in terms of manufacturing, drug release characteristics as well as release mechanism compared to small molecule loaded PLGA microsphere products. This is due to the complex structure of peptides, their hydrophilicity, charged state, large size and potential for instability. Moreover, therapeutic peptides are highly potent and therefore, an…
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