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3,389 results
  • PEGylated leuprolide with improved pharmacokinetic properties. [Journal Article]
    Bioorg Med Chem 2020; :115306Fu M, Zhuang X, … Zhang Y
  • Leuprolide, a gonadotropin-releasing hormone (GnRH) agonist widely used in androgen deprivation therapy for the treatment of advanced prostate cancer, suffers from a short circulating half-life like other peptide therapeutics. As an attempt to improve its pharmacokinetic properties, two PEGylated leuprolides with different molecular weight were synthesized utilizing N-hydroxysuccinimidyl (NHS) co…
  • Cutaneous endometriosis. [Case Reports]
    Int J Womens Dermatol 2019; 5(5):384-386Raffi L, Suresh R, … Twigg AR
  • Cutaneous endometriosis is a disorder that primarily affects women of reproductive age. The disorder is most commonly associated with cyclical pain during menses, but it can be difficult to diagnose in the absence of these symptoms and requires biopsy testing for a definitive diagnosis. We report on a case of a 41-year-old patient undergoing hormonal therapy for infertility who presented with a p…
  • StatPearls: Leuprolide [BOOK]
    StatPearls Publishing: Treasure Island (FL) Swayzer Dallas V. DV California Northstate University COM Gerriets Valerie V California Northstate University College of Medicine BOOK
  • Leuprolide is an FDA-approved gonadotropin-releasing hormone (GnRH) agonist used for the management of endometriosis, uterine leiomyomata (also known as uterine fibroids), treatment of central precocious puberty in children, and advanced prostate cancer. Off-label uses include management of breast cancer, hormone therapy for male to female transgender patients, premenopausal ovarian suppression, …
  • Vegetative Endocarditis due to Staphylococcus aureus in an Umbrella Cockatoo (Cacatua alba). [Journal Article]
    J Avian Med Surg 2019; 33(4):419-426Steinagel A, Quesenberry K, Donovan T
  • A 15-year-old, female cockatoo (Cacatua alba) was presented with a history of intermittent cloacal prolapse of 1-year duration. After each prolapse, the owner would digitally reduce the distended cloacal tissue within approximately 12-24 hours, for short-term resolution. The cockatoo was examined 3 times over a 7-month period and received supportive care with leuprolide acetate, behavioral modifi…
  • An 80-Year-Old Man With a 24-Hour History of Epigastric Pain. [Journal Article]
    Chest 2019; 156(6):e127-e131O'Brien CR, Li M, Morton C
  • An 80-year-old man was admitted to our hospital with 24 hours of epigastric pain. The pain was described as sharp, episodic, nonradiating, and without an identifiable provoking factor. Associated symptoms included nausea and nonbloody vomiting. He denied dyspnea, angina, fevers, chills, dysphagia, diarrhea, melena, or hematochezia. He had taken less than 2 g of acetaminophen earlier in the day wi…
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