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17,001 results
  • Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration. [Journal Article]
    Front Mol Neurosci 2019; 12:219O'Hara D, Davis GM, … Davey GP
  • Mitochondrial dysfunction is a recognized hallmark of neurodegenerative diseases and abnormal mitochondrial fusion-fission dynamics have been implicated in the pathogenesis of neurodegenerative disorders. This study characterizes the effects of metabolic flux inhibitors and activators on mitochondrial fusion dynamics in the neuronal cell culture model of differentiated PC12 cells. Using a real ti…
  • Metabolic Phenotyping in Venous Disease: The Need for Standardization. [Journal Article]
    J Proteome Res 2019Onida S, Tan MKH, … Davies AH
  • Venous thromboembolism (VTE), chronic venous disease (CVD), and venous leg ulceration (VLU) are clinical manifestations of a poorly functioning venous system. Though common, much is unknown of the pathophysiology and progression of these conditions. Metabolic phenotyping has been employed to explore mechanistic pathways involved in venous disease. A systematic literature review was performed: ful…
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