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754 results
  • Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury. [Journal Article]
    JCI Insight 2019Ward LA, Lee DS, … Gommerman JL
  • Subpial demyelination is a specific hallmark of multiple sclerosis (MS) and a correlate of disease progression. Although the mechanism(s) that mediate pathogenesis in the subpial compartment remain unclear, it has been speculated that inflammation in the overlying meninges may be associated with subpial injury. Here we show that adoptive transfer of proteolipid protein-primed Th17 cells into SJL/…
  • Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. [Review]
    Int J Mol Sci 2019; 20(21)Castro Dias M, Mapunda JA, … Engelhardt B
  • The homeostasis of the central nervous system (CNS) is ensured by the endothelial, epithelial, mesothelial and glial brain barriers, which strictly control the passage of molecules, solutes and immune cells. While the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) have been extensively investigated, less is known about the epithelial and mesothe…
  • Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging. [Journal Article]
    JCI Insight 2019; 4(20)Mazur C, Powers B, … Verma A
  • Intrathecal (IT) delivery and pharmacology of antisense oligonucleotides (ASOs) for the CNS have been successfully developed to treat spinal muscular atrophy. However, ASO pharmacokinetic (PK) and pharmacodynamic (PD) properties remain poorly understood in the IT compartment. We applied multimodal imaging techniques to elucidate the IT PK and PD of unlabeled, radioactively labeled, or fluorescent…
  • The CNS Immune Landscape from the Viewpoint of a T Cell. [Review]
    Trends Neurosci 2019; 42(10):667-679Mundt S, Greter M, … Becher B
  • Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but also appear to influence brain development and homeostasis. During immune surveillance, T cells can patrol the CNS-associated border regions to sense pathogenic alterations. While access to the CNS parenchyma is restricted in the steady state, various disease processes can initiate parenchymal T cell CNS in…
  • Response of the neurovascular unit to brain metastatic breast cancer cells. [Journal Article]
    Acta Neuropathol Commun 2019; 7(1):133Haskó J, Fazakas C, … Wilhelm I
  • Therapeutic resistance of cerebral secondary tumours largely depends on unique aspects linked to the neurovascular unit, especially cerebral endothelial cells and astrocytes. By using advanced microscopy techniques, here we explored novel mechanisms related to the neurovascular unit during extravasation and proliferation of triple negative breast cancer cells in the brain. Metastatic mammary carc…
  • Fibrinogen Chains Intrinsic to the Brain. [Journal Article]
    Front Neurosci 2019; 13:541Golanov EV, Sharpe MA, … Britz GW
  • We observed fine fibrin deposition along the paravascular spaces in naive animals, which increased dramatically following subarachnoid hemorrhage (SAH). Following SAH, fibrin deposits in the areas remote from the hemorrhage. Traditionally it is thought that fibrinogen enters subarachnoid space through damaged blood brain barrier. However, deposition of fibrin remotely from hemorrhage suggests tha…
  • Distillation of Posterior Fossa Demyelination in Acute Vestibular Syndrome: the Eyes Have It. [Editorial]
    Cerebellum 2019; 18(4):673-675Shaikh AG, Manto M
  • Separating the etiologies of an acute vestibular syndrome (AVS) of central origin is a clinical challenge; the common causes include (1) stroke of the brainstem/cerebellum and (2) demyelinating disorders such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Overshadowed by the vascular etiologies, the literature describing AVS due to demyelinating disorders has been …
  • Angiocentric astrocytoma in a cat. [Case Reports]
    J Vet Diagn Invest 2019; 31(4):576-580Rissi DR, McHale BJ, Armién AG
  • Gliomas are common primary central nervous system neoplasms of dogs and cats, but atypical glioma subtypes are rare. Herein we report an angiocentric astrocytoma in a 15-y-old spayed female domestic shorthaired cat that was euthanized after therapy-resistant seizures. Gross anatomic changes consisted of swelling of the rostral leptomeninges over the olfactory bulbs and rostral telencephalon. Hist…
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