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278 results
  • Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis. [Journal Article]
    Lancet Gastroenterol Hepatol 2019Luthra P, Camilleri M, … Ford AC
  • CONCLUSIONS: Almost all drugs studied were superior to placebo, according to either failure to achieve three or more CSBMs per week or or failure to achieve an increase of one or more CSBM per week over baseline. Although diphenyl methane laxatives ranked first at 4 weeks, patients with milder symptoms might have been included in these trials. Prucalopride ranked first at 12 weeks, and many of the included trials recruited patients who previously did not respond to laxatives, suggesting that this drug is likely to be the most efficacious for patients with chronic idiopathic constipation. However, because treatment duration in most trials was 4-12 weeks, the long-term relative efficacy of these drugs is unknown.
  • What's in the pipeline for lower functional gastrointestinal disorders in the next 5 years? [Journal Article]
    Am J Physiol Gastrointest Liver Physiol 2019Camilleri M
  • The overall objectives of this review are to summarize actionable biomarkers for organic etiology of lower functional gastrointestinal diseases (FGIDs) that lead to individualized treatment for their FGIDs, and to assess the pipeline for novel approaches to the management of constipation, diarrhea, and chronic abdominal pain in lower FGIDs. The new approaches to therapy include ion exchangers/tra…
  • [Constipation - pathophysiology, diagnostics, treatment]. [Journal Article]
    Dtsch Med Wochenschr 2019; 144(16):1145-1157Müller-Lissner S
  • The most relevant risk factors for the development of chronic constipation are neurologic disorders such as Parkinson's disease, immobility, and some drugs, in particular opioids. A proctologic exam and exclusion of red flags form part of the basic assessment. The currently available laxatives are effective and safe, habituation and tolerance (tachyphylaxis) being an exception. Also long-term int…
  • Clinical Efficacy and Safety Profile of Prucalopride in Chronic Idiopathic Constipation. [Review]
    Cureus 2019; 11(4):e4382Tameez Ud Din A, Khan AH, … Malik MN
  • Chronic idiopathic constipation (CIC) can be defined as bowel movements that are difficult to pass, are not occurring frequently, or have incomplete evacuation during defecation. A high-fiber diet and laxatives are the commonly used treatments, but in many cases, they do not produce satisfactory results. The first line of treatment is osmotic laxatives. If there is no improvement, the second line…
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