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(lipocyte)
38,081 results
  • Activation of HCAR2 by niacin: benefits beyond lipid lowering. [Journal Article]
    Pharmacogenomics 2019Tuteja S
  • Niacin (nicotinic acid) is a potent lipid-lowering agent that has been used for prevention of coronary heart disease. Niacin activates the HCAR2 receptor found on adipocytes, macrophages and various immune cells throughout the body. Activation of the HCAR2 receptor by niacin results in beneficial anti-inflammatory effects that are independent of lipid lowering. This review summarizes the use of n…
  • The Beige Adipocyte as a Therapy for Metabolic Diseases. [Review]
    Int J Mol Sci 2019; 20(20)Lizcano F
  • Adipose tissue is traditionally categorized into white and brown relating to their function and morphology. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue more energetically active, with a greater number of mitochondria and energy production in the form of heat.…
  • Effects of Adipocyte-derived Factors on the Adrenal Cortex. [Journal Article]
    Curr Mol Pharmacol 2019Shimada H, Noro E, … Sugawara A
  • CONCLUSIONS: Since CYP11B1 is well known as a limiting enzyme of cortisol synthesis, our study suggests that adipocyte-derived factors may stimulate cortisol secretion, as well as aldosterone secretion. Taken together, adipocyte-derived factors may be the cause of metabolic syndrome due to their stimulating effects on aldosterone/cortisol secretion. Therefore, the innovation of novel drugs against them may possibly be a new approach against metabolic syndrome.
  • The clinical potential of circulating microRNAs in obesity. [Review]
    Nat Rev Endocrinol 2019Ji C, Guo X
  • Obesity is a complex condition that is characterized by excessive fat accumulation, which can lead to the development of metabolic disorders, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease and cardiovascular diseases. Evidence is accumulating that circulating microRNAs (miRNAs) act as a new class of endocrine factor. These miRNAs are released by many types of tissue, including…
  • Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. [Journal Article]
    Sci Rep 2019; 9(1):14779Lackey DE, Reis FCG, … Osborn O
  • Insulin resistance is a key feature of obesity and type 2 diabetes. PU.1 is a master transcription factor predominantly expressed in macrophages but after HFD feeding PU.1 expression is also significantly increased in adipocytes. We generated adipocyte specific PU.1 knockout mice using adiponectin cre to investigate the role of PU.1 in adipocyte biology, insulin and glucose homeostasis. In HFD-fe…
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