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(lipopenia)
9 results
  • [Cockayne syndrome]. [Case Reports]
    Zhongguo Dang Dai Er Ke Za Zhi 2011; 13(2):141-4Wang XM, Cui YP, … Zheng ZZ
  • Cockayne syndrome is a rare autosomal recessive disease. This paper reports a case of Cockayne syndrome confirmed by gene analysis. The baby (male, 7 years old) was referred to Peking University Third Hospital with recurrent desquamation, pigmentation and growth and development failure for 6 years, and recurrent dental caries and tooth loss for 2 years. Physical examination showed very low body w…
  • Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. [Journal Article]
    J Biol Chem 2004; 279(12):11767-76Stone SJ, Myers HM, … Farese RV
  • The synthesis of triglycerides is catalyzed by two known acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes. Although they catalyze the same biochemical reaction, these enzymes share no sequence homology, and their relative functions are poorly understood. Gene knockout studies in mice have revealed that DGAT1 contributes to triglyceride synthesis in tissues and plays an important role in reg…
  • Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity. [Journal Article]
    Am J Physiol Regul Integr Comp Physiol 2003; 285(5):R1011-20Wilsey J, Zolotukhin S, … Scarpace PJ
  • The objective of this study was to determine if central overexpression of leptin could overcome the leptin resistance caused by 100 days of high-fat feeding. Three-month old-F344XBN male rats were fed either control low fat chow (Chow), which provides 15% of energy as fat, or a high-fat/high-sucrose diet (HF), which provides 59% of energy as fat. Over several weeks, the HF-fed animals spontaneous…
  • Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity. [Journal Article]
    J Clin Invest 1997; 100(7):1750-4Shimabukuro M, Koyama K, … Unger RH
  • Interleukin 1beta (IL-1beta)-induced beta cell cytotoxicity has been implicated in the autoimmune cytotoxicity of insulin-dependent diabetes mellitus. These cytotoxic effects may be mediated by nitric oxide (NO). Since long-chain fatty acids (FFA), like IL-1beta, upregulate inducible nitric oxide synthase and enhance NO generation in islets, it seemed possible that islets might be protected from …
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