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458 results
  • Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity. [Journal Article]
    Adv Exp Med Biol. 2020 Feb 20 [Online ahead of print]Maselli DB, Camilleri M
  • The processing of proglucagon in intestinal L cells results in the formation of glucagon, GLP-1, and GLP-2. The GLP-1 molecule becomes active through the effect of proconvertase 1, and it is inactivated by dipeptidyl peptidase IV (DPP-IV), so that the half-life of endogenous GLP-1 is 2-3 min. GLP-1 stimulates insulin secretion from β cells in the islets of Langerhans. Human studies show that infu…
  • Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking. [Journal Article]
    Chem Sci. 2019 Nov 14; 10(42):9872-9879.Fremaux J, Venin C, … Goudreau SR
  • The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of α-amino acid residues with ureido units at selected positions in peptides to improve potency and generate effective incretin mimics. Based on molecular dynamics simulations, N-terminally modified GLP-1 an…
  • Renal outcomes with the newer antidiabetes drugs: the era before and after CREDENCE. [Review]
    Diabet Med. 2020 Apr; 37(4):593-601.Rajani A, Sahay M, … Amar A
  • In 2008, the US Food and Drug Administration provided guidance for the evaluation of the cardiovascular safety of antidiabetes drugs. The newer antidiabetes drugs, approved after 2008, were therefore evaluated in long-term cardiovascular outcome trials, designed and powered for the assessment of cardiovascular safety. Accordingly, the primary endpoint of these trials was a cardiac composite endpo…
  • StatPearls: Glucagon-like Peptide-1 Receptor Agonists [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Collins Logan L St. Bernards Medical Center Costello Ryan A. RA BOOK
  • Glucagon-like peptide-1 (GLP-1) agonists represent a class of medications used in the treatment of type 2 diabetes mellitus in adults. Examples of drugs in this class include exenatide, lixisenatide, liraglutide, albiglutide, dulaglutide, and semaglutide. According to the American Diabetes Association, metformin remains the preferred first-line therapy for the treatment of type 2 diabetes. Howeve…
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