Download the Free Prime PubMed App to your smartphone or tablet.

Available for iPhone or iPad:

Unbound PubMed app for iOS iPhone iPadAlso Available:
Unbound PubMed app for Android

Available for Mac and Windows Desktops and laptops:

Unbound PubMed app for Windows
606 results
  • New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. [Journal Article]
    AAPS J 2018; 20(2):29Lee NR, Zheng G, … Dwoskin LP
  • Despite increased methamphetamine use worldwide, pharmacotherapies are not available to treat methamphetamine use disorder. The vesicular monoamine transporter-2 (VMAT2) is an important pharmacological target for discovery of treatments for methamphetamine use disorder. VMAT2 inhibition by the natural product, lobeline, reduced methamphetamine-evoked dopamine release, methamphetamine-induced hype…
  • Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease. [Review]
    J Ethnopharmacol 2018; 215:42-73Sahoo AK, Dandapat J, … Kanhar S
  • CONCLUSIONS: A successful validation of the CDMT strategy may open up a debate on health care reform to explore other possibilities of combination therapy. In doing so, it should focus on clinical and molecular relationships between AD and CDMT. A better understanding of these relationships could inform and impact future development of AD-directed treatment strategies. This strategy also involves in reducing costs in treatment phases which will be affordable to a common man suffering from AD.
  • Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds. [Journal Article]
    Nat Commun 2017; 8(1):1484Sung HY, Jeong YT, … Moon SJ
  • Animals must detect aversive compounds to survive. Bitter taste neurons express heterogeneous combinations of bitter receptors that diversify their response profiles, but this remains poorly understood. Here we describe groups of taste neurons in Drosophila that detect the same bitter compounds using unique combinations of gustatory receptors (GRs). These distinct complexes also confer responsive…
  • Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. [Journal Article]
    Alcohol 2017; 61:63-70Roni MA, Rahman S
  • Evidence indicates that the brain nicotinic acetylcholine receptor (nAChRs) ligand lobeline reduces depression-like behaviors, ethanol drinking, and nicotine withdrawal-induced depression-like behaviors. The purpose of the present study was to determine the effects of lobeline on ethanol abstinence-induced depression-like behavior and associated neuroadaptive changes in mice. Adult C57BL/6J male …
New Search Next