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151,468 results
  • Mitotic Index and Progression Free Survival in Atypical Meningiomas. [Review]
    World Neurosurg. 2020 Jun 29 [Online ahead of print]Domingo RA, Tripathi S, … Quiñones-Hinojosa A
  • Extent of resection and tumor grade are considered as the most important predictor of progression free survival (PFS) in meningiomas. However, adjuvant therapy for atypical meningiomas remains controversial, with variable PFS rates of up to 40%. Current Mitotic Index (MI) range for atypical meningiomas is broad, comprising all tumors with >4 and <20 mitotic count per 10 HPF; leading to substantia…
  • Sternal Resection and Reconstruction with a Novel Modularized Prosthesis. [Journal Article]
    Ann Thorac Surg. 2020 Jun 29 [Online ahead of print]Wang H, Liu Z, … Jiang G
  • CONCLUSIONS: The most prominent advantage of this system is that there is no need for individualized design and manufacture before surgery. Therefore, this modularized system is potentially widely applicable as an adaptable and effective prosthesis for sternal reconstruction.
  • Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion) in Pediatric Phalanges. [Case Reports]
    J Hand Surg Am. 2020 Jun 28 [Online ahead of print]Martínez Álvarez S, Azorín Cuadrillero DL, Little KJ
  • Bizarre parosteal osteochondromatous proliferation, or Nora tumor, is an uncommon lesion affecting the tubular bones of the hands and feet. Normally arising from the cortical surface and periosteum of these bones, these lesions histologically consist of a hypercellular cartilaginous cap covering a bony stalk that is surrounded by ossified areas and spindle cell stroma. The differential diagnosis …
  • Management of Refractory Pediatric Sarcoma: Current Challenges and Future Prospects. [Review]
    Onco Targets Ther. 2020; 13:5093-5112.Pushpam D, Garg V, … Biswas B
  • Paediatric sarcomas are a heterogeneous group of disorders constituting bone sarcoma and various soft tissue sarcomas. Almost one-third of these presents with metastasis at baseline and another one-third recur after initial curative treatment. There is a huge unmet need in this cohort in terms of curative options and/or prolongation of survival. In this review, we have discussed the current treat…
  • Middle ear adenomatous neuroendocrine tumors: suggestion for surgical strategy. [Journal Article]
    Braz J Otorhinolaryngol. 2020 Jun 15 [Online ahead of print]Xie B, Zhang S, … Liu Y
  • CONCLUSIONS: Complete surgical resection provided good results for patients with middle ear adenomatous neuroendocrine tumors. The ossicular chain should be removed. Because of the propensity for local recurrence and invasiveness, as well as regional or distant metastasis of these tumors, it is necessary to schedule long-term follow-up and an observation plan postoperatively.
  • Progress in Local Treatment of Breast Cancer: A Narrative Review. [Journal Article]
    Rev Bras Ginecol Obstet. 2020 Jun; 42(6):356-364.Cavalcante FP, Millen EC, … Novita GG
  • The present paper reports on the local treatment of breast cancer from a historical perspective. A search for articles written in English was made in the Medline and EMBASE databases, and 40 papers were selected. Over the past 10 years, various randomized, controlled clinical trials on the local treatment of breast cancer indicated that patients with the same molecular subtype may receive differe…
  • Ingenol mebutate for the management of cryotherapy-resistant anogenital warts. [Journal Article]
    Dermatol Ther. 2020 Jun 30 [Online ahead of print]Shahidi Dadras M, Hoormand M, … Mozafari N
  • Ingenol Mebutate (IM), as an active compound is derived from the sap of the Euphorbia peplus, which is an FDA -approved plant for the treatment of actinic keratosis. Some reports have demonstrated that the IM gel 0.05% is safe and effective in the treatment of external anogenital warts but the efficacy of the drug on the recalcitrant anogenital warts is not clear. to assess the efficacy and safet…
  • Management options for Vaginal Intraepithelial Neoplasia. [Review]
    Int J Clin Pract. 2020 Jun 29 [Online ahead of print]Rountis A, Pergialiotis V, … Haidopoulos D
  • CONCLUSIONS: The choice of treatment depends upon many factors. Surgical excision is the mainstay of treatment and should be performed if invasion cannot be excluded. Topical agents are useful for persistent, multifocal lesions or for women that cannot undergo surgical treatment. Brachytherapy is associated with high morbidity rates and should be reserved for women who have multifocal disease, are poor surgical candidates and/or have failed other treatments. CO2 laser ablation achieves minimal scarring and sexual dysfunction; however invasive disease should be ruled out with biopsies before the initiation of the treatment.
  • Tumour budding and its clinical implications in gastrointestinal cancers. [Review]
    Br J Cancer. 2020 Jun 30 [Online ahead of print]Zlobec I, Berger MD, Lugli A
  • Tumour budding in colorectal cancer has become an important prognostic factor. Represented by single cells or small tumour cell clusters at the invasion front of the tumour mass, these tumour buds seem to reflect cells in a 'hybrid' state of epithelial-mesenchymal transition, and evidence indicates that the presence of these entities is associated with lymph node metastasis, local recurrence and …
  • Endoscopic Curettage and Bone Grafting of Intraosseous Ganglion of the Second Metatarsal. [Case Reports]
    J Foot Ankle Surg. 2020 Jul - Aug; 59(4):807-812.Lui TH
  • Intraosseous ganglion is a benign cystic lesion located in the subchondral region and in the epiphyseal areas of long and short tubular bones. It occasionally extends to the metaphysis and diaphysis regions and rarely involves the metatarsal bone. In this report, a case of intraosseous ganglion of the second metatarsal extending from metaphysis to diaphysis was presented. This presented with dull…
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