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2,667 results
  • Medulloblastoma in a 6 Year Old Mixed Breed Dog: Surgical Debulking and Chemotherapy. [Case Reports]
    Front Vet Sci 2019; 6:401Lampe R, Vieson MD, … Selting KA
  • A medulloblastoma was surgically debulked from a 6 year old American Staffordshire Terrier, who then received a modified lomustine (CCNU), vincristine, procarbazine, and prednisolone (LOPP) protocol. The dog improved significantly and continued to do well until deterioration and euthanasia 5 months following surgery. This is the first known published case report of surgical cytoreductive surgery …
  • Post-remission therapy in acute myeloid leukemia: Are we ready for an individualized approach? [Review]
    Best Pract Res Clin Haematol 2019; 32(4):101102Derman BA, Larson RA
  • Recent advances in remission induction treatment strategies for acute myeloid leukemia (AML) have improved the rates of complete remission (CR) and overall survival (OS), owing to a concerted effort to tailor therapies toward specific AML subtypes. However, without effective post-remission therapy, most patients will relapse. The extent to which post-remission therapies is individualized in the c…
  • Radiation and chemotherapy for high-risk lower grade gliomas: Choosing between temozolomide and PCV. [Review]
    Cancer Med 2019McDuff SGR, Dietrich J, … Shih HA
  • CONCLUSIONS: At present, we conclude that current evidence does not support the widespread use of TMZ over PCV for all patients with high-risk LGG, and we instead recommend tailoring chemotherapy recommendation based on IDH status, favoring adjuvant PCV for patients with any IDH mutant tumors, both those that harbor 1p/19q codeletion and those non-1p/19q codeleted. Given the critical role radiation plays in the treatment of LGG, radiation oncologists should be actively involved in discussions regarding chemotherapy choice in order to optimize treatment for their patients.
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Lomustine [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Lomustine is an orally administered alkylating agent used alone and in combination with other antineoplastic agents in the treatment of several malignancies including Hodgkin disease, lymphoma, and brain cancer. Lomustine therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury.
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