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17,720 results
  • A longitudinal model of periprosthetic joint infection in the rat. [Journal Article]
    J Orthop Res 2019Fan Y, Xiao Y, … Oral E
  • The majority of periprosthetic joint infections occur shortly after primary joint replacement (<3 months) and require the removal of all implant components for the treatment period (~4 months). A clinically relevant animal model of periprosthetic infection should therefore establish an infection with implant components in place. Here we describe a joint replacement model in the rat with ultrahigh…
  • Joint-preservation surgery for pediatric osteosarcoma of the knee joint. [Review]
    Cancer Metastasis Rev 2019Takeuchi A, Yamamoto N, … Tsuchiya H
  • The multi-disciplinary approach involving imaging, multi-agent chemotherapy, meticulous surgical procedures, and careful postoperative care has facilitated an increase in the use of limb-sparing surgery for pediatric osteosarcoma. Osteosarcoma usually occurs around the metaphysis of the distal femur or proximal tibia and needs wide excision with the adjacent joint and replacement by a megaprosthe…
  • Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment. [Review]
    J Clin Med 2019; 8(12)Goodman SB, Gallo J
  • Clinical studies, as well as in vitro and in vivo experiments have demonstrated that byproducts from joint replacements induce an inflammatory reaction that can result in periprosthetic osteolysis (PPOL) and aseptic loosening (AL). Particle-stimulated macrophages and other cells release cytokines, chemokines, and other pro-inflammatory substances that perpetuate chronic inflammation, induce osteo…
  • Is Isolated Mobile Component Exchange an Option in the Management of Intraprosthetic Dislocation of a Dual Mobility Cup? [Journal Article]
    Clin Orthop Relat Res 2019Wegrzyn J, Malatray M, … Béjui-Hugues J
  • CONCLUSIONS: A failure rate of 18% (28 of 153 patients undergoing isolated mobile component exchange) was reported within 5 years after isolated mobile component exchange to manage intraprosthetic dislocation occurring with a well-fixed dual mobility cup metal shell. The two modes of failure were early recurrence of intraprosthetic dislocation or severe premature metallosis-related polyethylene wear of the mobile component with loosening of the dual mobility cup. Acetabular revision with synovectomy should remain the standard procedure to manage intraprosthetic dislocation, particularly if periarticular metallosis is present. The exception is intraprosthetic dislocation occurring in elderly or frail patients, for whom a conventional acetabular revision procedure would be associated with an unjustified surgical or anesthetic risk.
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