- Long-term outcome of cemented total hip arthroplasty with the Charnley-type femoral stem made of titanium alloy. [Journal Article]J Orthop Sci 2019JO
- CONCLUSIONS: Cemented primary total hip arthroplasty with the Charnley-type femoral stem made of Ti alloy showed excellent outcomes for more than 20 years.
- [Treatment of benign tumors in thoracic spinal canal by modified replanting posterior ligament complex applying piezoelectric osteotomy]. [Journal Article]Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019; 33(8):991-995ZX
- CONCLUSIONS: Modified replanting PLC applying piezoelectric osteotomy and micro-reconstruction with titanium plate for the primary benign tumors in thoracic spinal canal can reconstruct the anatomy of the spinal canal, enable patients to recover daily activities quickly. It is an effective and safe treatment.
- Repair Effects of KGF on Ischemia-Reperfusion-Induced Flap Injury via Activating Nrf2 Signaling. [Journal Article]J Surg Res 2019; 244:547-557JS
- CONCLUSIONS: KGF played an important role in protecting mice flaps from IR injury, and the possible mechanism was involved in activating the Nrf2 signaling.
- Does migration of osseointegrated implants for transfemoral amputees predict later revision? A prospective 2-year radiostereometric analysis with 5-years clinical follow-up. [Journal Article]Orthop Traumatol Surg Res 2019OT
- CONCLUSIONS: Later removed OI implants migrated from 3 months to last follow-up and more than the non-removed OI implants. Distal implant migration greatly increased the odds of implant removal. Ten out of 17 OI implants were removed within 5 years of follow-up. We advise to use OI implants with caution and close follow-up in consideration of the risk of complications.
- Genomic prediction offers the most effective marker assisted breeding approach for ability to prevent arsenic accumulation in rice grains. [Journal Article]PLoS One 2019; 14(6):e0217516Plos
- The high concentration of arsenic (As) in rice grains, in a large proportion of the rice growing areas, is a critical issue. This study explores the feasibility of conventional (QTL-based) marker-assisted selection and genomic selection to improve the ability of rice to prevent As uptake and accumulation in the edible grains. A japonica diversity panel (RP) of 228 accessions phenotyped for As con…
The high concentration of arsenic (As) in rice grains, in a large proportion of the rice growing areas, is a critical issue. This study explores the feasibility of conventional (QTL-based) marker-assisted selection and genomic selection to improve the ability of rice to prevent As uptake and accumulation in the edible grains. A japonica diversity panel (RP) of 228 accessions phenotyped for As concentration in the flag leaf (FL-As) and in the dehulled grain (CG-As), and genotyped at 22,370 SNP loci, was used to map QTLs by association analysis (GWAS) and to train genomic prediction models. Similar phenotypic and genotypic data from 95 advanced breeding lines (VP) with japonica genetic backgrounds, was used to validate related QTLs mapped in the RP through GWAS and to evaluate the predictive ability of across populations (RP-VP) genomic estimate of breeding value (GEBV) for As exclusion. Several QTLs for FL-As and CG-As with a low-medium individual effect were detected in the RP, of which some colocalized with known QTLs and candidate genes. However, less than 10% of those QTLs could be validated in the VP without loosening colocalization parameters. Conversely, the average predictive ability of across populations GEBV was rather high, 0.43 for FL-As and 0.48 for CG-As, ensuring genetic gains per time unit close to phenotypic selection. The implications of the limited robustness of the GWAS results and the rather high predictive ability of genomic prediction are discussed for breeding rice for significantly low arsenic uptake and accumulation in the edible grains.
- Early Clinical Outcome of Lumbar Spinal Fixation With Cortical Bone Trajectory Pedicle Screws in Patients With Osteoporosis With Degenerative Disease. [Journal Article]Orthopedics 2019; :1-7O
- This cohort study aimed to elucidate early surgical outcomes after midline lumbar fusion (MidLIF) with cortical bone trajectory (CBT) screw fixation compared with transforaminal lumbar interbody fusion (TLIF) using traditional pedicle screw (TPS) fixation for lumbar degenerative disease (LDD) in patients with osteoporosis. The authors randomly assigned 70 patients with osteoporosis who had LDD at…
This cohort study aimed to elucidate early surgical outcomes after midline lumbar fusion (MidLIF) with cortical bone trajectory (CBT) screw fixation compared with transforaminal lumbar interbody fusion (TLIF) using traditional pedicle screw (TPS) fixation for lumbar degenerative disease (LDD) in patients with osteoporosis. The authors randomly assigned 70 patients with osteoporosis who had LDD at 1 or 2 adjacent vertebral levels to undergo either MidLIF with CBT (CBT group) or TLIF with TPS fixation (TPS group) from February 2015 to March 2016. Pre- and postoperative lumbar Japanese Orthopaedic Association (JOA) scale scores were assessed and radiographic measurements on dynamic plain radiographs and computed tomography images were analyzed. The final data analysis included 31 patients in the CBT group (mean age, 73.42±6.74 years; t-score, -2.94±0.75) and 32 patients in the TPS group (mean age, 74.84±5.37 years; t-score, -2.92±0.66). Mean JOA score improved significantly in both groups, although no intragroup differences of JOA score improvement were found at the latest follow-up evaluation (P>.05). In addition, significantly higher rates of screw loosening (28.13% vs 6.5%, P=.03) and the amount of subsidence (3.01±0.52 vs 2.49±0.45 mm, P=.02) were found in the TPS group. Rate of radiographic fusion of both groups showed no statistical difference. Both groups of patients achieved a similar rate of radiographic fusion at the 1.5-year follow-up and experienced similar intra- or postoperative complications and postoperative recovery. The MidLIF with CBT screw fixation for short-level lumbar fusion in patients with osteoporosis provided improvement of clinical symptoms comparable to that of TLIF using traditional TPS fixation. In addition, statistically significant lumbar stability was found in the CBT group compared with the TPS group. [Orthopedics. 201x; xx(x):xx-xx.].
- Fifty-six percent of proximal femoral cortical hypertrophies 6 to 10 years after Total hip arthroplasty with a short Cementless curved hip stem - a cause for concern? [Journal Article]BMC Musculoskelet Disord 2019; 20(1):261BM
- CONCLUSIONS: The percentage of cortical hypertrophies remained almost constant in the mid-term compared to the short-term with the present cementless short hip stem design. The high percentage of cortical hypertrophies seems not be a cause for concern with this specific implant in the mid-term.
- What Is the Risk of Repeat Revision When Patellofemoral Replacement Is Revised to TKA? An Analysis of 482 Cases From a Large National Arthroplasty Registry. [Journal Article]Clin Orthop Relat Res 2019; 477(6):1402-1410CO
- CONCLUSIONS: The risk of second revision when a PFR is revised is not altered if cruciate-retaining or posterior-stabilized TKA is used for the revision nor if the patella component is revised or not revised. The risk of repeat revision after revision of a PFR to a TKA was much higher than the risk of revision after a primary TKA, and these findings did not change when we analyzed only devices in use since 2005. When PFR is used for the management of isolated patellofemoral osteoarthritis, patients should be counselled not only about the high revision rate of the primary procedure, but also the revision rate after TKA. Further studies regarding the functional outcomes of these procedures may help clarify the value of PFRs and subsequent revisions.
- Are Hooded, Crosslinked Polyethylene Liners Associated with a Reduced Risk of Revision After THA? [Journal Article]Clin Orthop Relat Res 2019; 477(6):1315-1321CO
- CONCLUSIONS: Prior research has suggested that hooded acetabular liners may be associated with impingement, loosening, and osteolysis; however, in this large, registry-based report we found that XLPE hooded liners are not associated with an increased revision rate for aseptic loosening/osteolysis. Although there are many potential confounding variables in this registry analysis, if anything, surgeons using larger femoral heads and hooded liners likely did so in patients with a higher perceived dislocation risk. Patients with larger heads and XLPE hooded liners were, however, less likely to experience revision for dislocation. These liners therefore appear reasonable to use in primary THA at the surgeon's discretion.
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- Outcome of 881 total hip arthroplasties in 747 patients 21 years or younger: data from the Nordic Arthroplasty Register Association (NARA) 1995-2016. [Journal Article]Acta Orthop 2019; 90(4):331-337AO
- Background and purpose - The literature is scarce on the outcome of the youngest patients with total hip arthroplasties (THAs). We analyzed register data, revision risk, and related factors in patients 21 years or younger with THAs in the Nordic Arthroplasty Register Association (NARA). Patients and methods - We included all THA patients 21 years or younger reported during 1995 through 2016 to th…
Background and purpose - The literature is scarce on the outcome of the youngest patients with total hip arthroplasties (THAs). We analyzed register data, revision risk, and related factors in patients 21 years or younger with THAs in the Nordic Arthroplasty Register Association (NARA). Patients and methods - We included all THA patients 21 years or younger reported during 1995 through 2016 to the Danish, Finnish, Norwegian, and Swedish hip arthroplasty registers and merged these into the NARA dataset. Primary outcome was any implant revision. Results - We identified 881 THAs in 747 patients. Mean age at primary surgery was 18 years (9-21). The indications for THA were pediatric hip diseases (33%), systemic inflammatory disease (23%), osteoarthritis (4%), avascular necrosis (12%), hip fracture sequelae (7%), and other diagnoses (21%). Unadjusted 10-year survival for all THAs was 86%. Comparison between indications showed no differences in survival. Uncemented implants were used most frequently. Survival for uncemented and cemented implants was the same adjusted for sex, indication, head size, and time period for primary surgery. Aseptic loosening was the main cause of revision. Interpretation - Both cemented and uncemented fixations seem to be a viable option in this age group, but with a lower implant survival than in older patient groups.