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1,557 results
  • Anticholinergic and sedative medications exposure in older patients: a cross-sectional study. [Journal Article]
    Int J Clin Pharm 2019Zhang X, Zhou S, … Liu X
  • Background The Drug Burden Index is a risk assessment tool used to quantify anticholinergic and sedative medications burden of older patients. There have been no previously published reports the exposure of anticholinergic and sedative medications in China. Objective We investigated the prevalence and correlates risk factors of anticholinergic and sedative medications in hospitalized older patien…
  • Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine. [Journal Article]
    Pharmacol Res Perspect 2019; 7(4):e00499Nakamura T, Hiraoka K, … Okamura N
  • Some histamine H1 receptor (H1R) antagonists induce adverse sedative reactions caused by blockade of histamine transmission in the brain. Desloratadine is a second-generation antihistamine for treatment of allergic disorders. Its binding to brain H1Rs, which is the basis of sedative property of antihistamines, has not been examined previously in the human brain by positron emission tomography (PE…
  • Pharmacological Characterization of Mouse Hind Paw Edema Induced by Parachartergus fraternus Venom. [Journal Article]
    Inflammation 2019de Araujo Isaias Muller J, Mortari MR, … Toffoli-Kadri MC
  • Stings from the wasp Parachartergus fraternus occur throughout Latin America, and edema followed by pain is the main symptom presented by victims. This often limited inflammatory event has not been characterized for this species. In this work, we identified the mechanisms and possible mediators involved in this response. P. fraternus venom (100, 200, and 400 μg/kg) was injected into the hind paws…
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