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Unbound Medicine.
(lung protective strategy)
1,336 results
  • Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. [Journal Article]
    Front Endocrinol (Lausanne). 2020; 11:388.Ferreira TPT, Lima JGME, … Silva PMRE
  • Silicosis is an occupational disease triggered by the inhalation of fine particles of crystalline silica and characterized by inflammation and scarring in the form of nodular lesions in the lungs. In spite of the therapeutic arsenal currently available, there is no specific treatment for the disease. Flunisolide is a potent corticosteroid shown to be effective for controlling chronic lung inflamm…
  • A case of endometrial carcinoma progressed during pregnancy resulting in fetal death. [Case Reports]
    Int Cancer Conf J. 2020 Jul; 9(3):159-161.Ota E, Nomura H, … Takeshima N
  • Most endometrial carcinomas (ECs) occurring during pregnancy are diagnosed in the first trimester. During the gestation period, progesterone level, which has a protective effect on the endometrium, is found to increase. In EC cases, administering high-dose progesterone is a therapeutic strategy because this hormone can considerably shrink tumors. Herein, the case of a woman in whom EC progressed …
  • Impact of high tidal volume ventilation on surfactant metabolism and lung injury in infant rats. [Journal Article]
    Am J Physiol Lung Cell Mol Physiol. 2020 Jun 24 [Online ahead of print]Wiegert S, Greco F, … Cannizzaro V
  • The poorly understood tolerance towards high tidal volume (VT) ventilation observed in critically ill children and age-equivalent animal models may be explained by surfactant homeostasis. The aim of our prospective animal study was to test whether high VT with adequate positive end-expiratory pressure (PEEP) is associated with surfactant de novo synthesis and secretion leading to improved lung fu…
  • [Recommendations for treatment of severe coronavirus disease 2019 based on critical care ultrasound]. [Journal Article]
    Zhonghua Nei Ke Za Zhi. 2020 Jun 15; 59(0):E015.Zhang LN, Yin MG, … Chinese Critical Ultrasound Study Group, Chinese Society of Critical Care Medicine, Chinese Hemodynamic Therapy Collaboration Group of Critical Care Medicine
  • Severe patients with COVID-19 are characterized by persistent lung damage, causing respiratory failure, secondary circulatory changes and multiple organ dysfunction after virus invasion. Because of its dynamic, real-time, non-invasive, repeatable and other advantages, critical ultrasonography can be widely used in the diagnosis, assessment and guidance of treatment for severe patients. Based on t…
  • Lung and Diaphragm-Protective Ventilation. [Journal Article]
    Am J Respir Crit Care Med. 2020 Jun 09 [Online ahead of print]Goligher EC, Dres M, … Pleural Pressure Working Group, Acute Respiratory Failure Section of the European Society of Intensive Care Medicine
  • Mechanical ventilation can cause acute diaphragm atrophy and injury and this is associated with poor clinical outcomes. While the importance and impact of lung-protective ventilation is widely appreciated and well-established, the concept of diaphragm-protective ventilation has recently emerged as a potential complementary therapeutic strategy. This Perspective, developed from discussions at a me…
  • Assessing Diaphragmatic Function. [Journal Article]
    Respir Care. 2020 Jun; 65(6):807-819.Schepens T, Fard S, Goligher EC
  • The diaphragm is vulnerable to injury during mechanical ventilation, and diaphragm dysfunction is both a marker of severity of illness and a predictor of poor patient outcome in the ICU. A combination of factors can result in diaphragm weakness. Both insufficient and excessive diaphragmatic contractile effort can cause atrophy or injury, and recent evidence suggests that targeting an appropriate …
  • COVID-19 pandemic: overview of protective-ventilation strategy in ARDS patients. [Journal Article]
    Acta Clin Belg. 2020 Apr 27 [Online ahead of print]Higny J, Feye F, Forêt F
  • CONCLUSIONS: We summarized the principal strategies for lung-protective ventilation of patients with ARDS. This focus is particularly addressed to physicians who are not experienced in the invasive respiratory management of ARDS patients. Nevertheless, it remains fundamental to acknowledge that new insights concerning this quickly spreading illness become available on a regular base.
  • Oxidized Phospholipids in Healthy and Diseased Lung Endothelium. [Review]
    Cells. 2020 Apr 15; 9(4)Karki P, Birukov KG
  • Circulating and cell membrane phospholipids undergo oxidation caused by enzymatic and non-enzymatic mechanisms. As a result, a diverse group of bioactive oxidized phospholipids generated in these conditions have both beneficial and harmful effects on the human body. Increased production of oxidized phospholipid products with deleterious effects is linked to the pathogenesis of various cardiopulmo…
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