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1,545 results
  • Role of bulge epidermal stem cells and TSLP signaling in psoriasis. [Journal Article]
    EMBO Mol Med 2019; :e10697Gago-Lopez N, Mellor LF, … Wagner EF
  • Psoriasis is a common inflammatory skin disease involving a cross-talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells (HF-SCs) in psoriasis is not well defined. Here, we show reduced expression of c-JUN and JUNB in bulge HF-SCs in patients with scalp psoriasis. Using lineage tracing in mouse models of skin inflammation …
  • Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma. [Journal Article]
    Expert Opin Investig Drugs 2019; :1-10Marone G, Spadaro G, … Varricchi G
  • Introduction: Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. TSLP exerts its effects by binding to a high affinity heteromeric receptor complex composed of TSLPR and IL-7Rα. An association of polymorphisms in TSLP with airway hyperresponsiveness, IgE, eosinophilia and asthma h…
  • Type I and type III interferons differ in their adjuvant activities for influenza vaccines. [Journal Article]
    J Virol 2019Ye L, Ohnemus A, … Staeheli P
  • Type I and type III interferons (IFN) can promote adaptive immune responses in mice and improve vaccine-induced resistance to viral infections. The adjuvant effect of type III IFN (IFN-λ) specifically boosts mucosal immunity by an indirect mechanism, involving IFN-λ-induced production of thymic stromal lymphopoietin (TSLP), a cytokine that activates immune cells. To date it remained unclear wheth…
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