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212 results
  • Freeze-dried plasma stability under prehospital field conditions. [Journal Article]
    Transfusion 2019Zur M, Glassberg E, … Avramovich E
  • CONCLUSIONS: Our data show minimal decreases in clotting factors in FDP after storage under field conditions, when compared to laboratory normal ranges. Along with the many advantages of FDP, this supports its use at the point of injury under battlefield conditions, despite uncontrolled storage environments. Under controlled storage conditions at 4°C, shelf life could possibly be extended, although further study is required.
  • Optimization of Cancer Treatment in the Frequency Domain. [Journal Article]
    AAPS J 2019; 21(6):106Schulthess P, Rottschäfer V, … van der Graaf PH
  • Thorough exploration of alternative dosing frequencies is often not performed in conventional pharmacometrics approaches. Quantitative systems pharmacology (QSP) can provide novel insights into optimal dosing regimen and drug behaviors which could add a new dimension to the design of novel treatments. However, methods for such an approach are currently lacking. Recently, we illustrated the utilit…
  • Method to Predict Glass Vial Fogging in Lyophilized Drug Products. [Journal Article]
    J Pharm Sci 2019Langer C, Mahler HC, … Mathaes R
  • Glass fogging is a phenomenon occurring in lyophilized drug products and can be described as a thin product layer deposited on the inner surface of the glass container, in the area not covered by the lyo cake itself. It is often considered a cosmetic defect; however, the loss of container closure integrity is a potential consequence of the fogging's expansion to the vial neck region, making this …
  • Assessment of interstitial lung disease among black rheumatoid arthritis patients. [Journal Article]
    Clin Rheumatol 2019McFarlane IM, Zhaz SY, … Waite SA
  • CONCLUSIONS: Our study indicates RA-ILD among Blacks is predominantly a disease of elderly females with higher rates of GERD and CVD risk factors. Further studies are needed to identify the pathogenetic differences accounting for the gender distribution of RA-ILD among Black and White populations. Key Points • First study to assess ILD among predominantly Black RA patients. • The prevalence of RA-associated ILD was 6.36%, affecting mostly women in their sixth decade with seropositive disease. • COPD was the most common airway disease among non-RA-ILD Black population. • GERD was found in approximately one-third of patients with RA-associated ILD versus one-fifth of those RA patients without any lung disease.
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