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Unbound Medicine.
(mantra)
389 results
  • Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri. [Review]
    Front Immunol. 2020; 11:682.Piconese S, Campello S, Natalini A
  • "Location, location, and location": according to this mantra, the place where living beings settle has a key impact on the success of their activities; in turn, the living beings can, in many ways, modify their environment. This idea has now become more and more true for T cells. The ability of T cells to recirculate throughout blood or lymph, or to stably reside in certain tissues, turned out to…
  • Duct carcinoma in situ: A personal perspective. [Journal Article]
    Breast J. 2020 May 10 [Online ahead of print]Lagios MD
  • In the recent past, DCIS was a rare diagnosis established by biopsy of palpable breast masses or nipple changes. Mammography increased the frequency of a DCIS diagnosis by 20 × resulting in a tsunami of small circa 10 mm lesions detected only by mammography. The impact of pathologic technique in examining and characterizing such lesions is reviewed, and the development of algorithms incorporating…
  • Nick Martin and the Genetics of Depression: Sample Size, Sample Size, Sample Size. [Journal Article]
    Twin Res Hum Genet. 2020 May 08 [Online ahead of print]Byrne EM, Henders AK, … Wray NR
  • Nick Martin is a pioneer in recognizing the need for large sample size to study the complex, heterogeneous and polygenic disorders of common mental disorders. In the predigital era, questionnaires were mailed to thousands of twin pairs around Australia. Always quick to adopt new technology, Nick's studies progressed to phone interviews and then online. Moreover, Nick was early to recognize the va…
  • Prescribing and dosing exercise in primary care. [Journal Article]
    Aust J Gen Pract. 2020 04; 49(4):182-186.Orchard JW
  • Exercise prescription, while not traditionally part of the medical school curriculum or many advanced post-graduate training programs, is rapidly becoming an essential skill in primary care. Its importance relates to exercise being an effective evidence-based intervention for osteoarthritis, back pain, tendinopathy, some cancers, depression, diabetes and cardiovascular diseases.
  • Conversion to secondary progressive multiple sclerosis: Multistakeholder experiences and needs in Italy. [Multicenter Study]
    PLoS One. 2020; 15(2):e0228587.Giovannetti AM, Pietrolongo E, … ManTra Project
  • CONCLUSIONS: Two are the main findings: first, the widespread lack of awareness around the transition; second, the need to improve the quality of the care pathway in the Italian context. It was particularly stressed the need for a holistic and multidisciplinary approach (with patients and SOs as members of the team), the development of an ad hoc plan of follow up visits with easy access to MS specialists' consultation/treatment; specialized training for each stakeholders; more information on SPMS, daily management and changes at policy level.
  • Tasting the terroir of wine yeast innovation. [Journal Article]
    FEMS Yeast Res. 2020 Feb 01; 20(1)Pretorius IS
  • Wine is an archetypal traditional fermented beverage with strong territorial and socio-cultural connotations. Its 7000 year history is patterned by a tradition of innovation. Every value-adding innovation - whether in the vineyard, winery, supply chain or marketplace - that led to the invention of a new tradition spurred progress and created a brighter future from past developments. In a way, win…
  • Tantra and Modern Neurosciences: Is there any Correlation? [Review]
    Neurol India. 2019 Sep-Oct; 67(5):1188-1193.Venkatraman A, Nandy R, … Jayasundar R
  • CONCLUSIONS: Systematic exploration of Tantric texts can be of tremendous value in expanding our understanding of human beings' experiential reality, by enabling us to build bridges between first-person and third-person approaches to the nervous system. This may open up new avenues for cognitive enhancement and treating neurological diseases.
  • What Is Meditation? Proposing an Empirically Derived Classification System. [Journal Article]
    Front Psychol. 2019; 10:2276.Matko K, Sedlmeier P
  • Meditation is an umbrella term, which subsumes a huge number of diverse practices. It is still unclear how these practices can be classified in a reasonable way. Earlier proposals have struggled to do justice to the diversity of meditation techniques. To help in solving this issue, we used a novel bottom-up procedure to develop a comprehensive classification system for meditation techniques. In p…
  • To Be or Not to Be Vaccinated? The Ethical Aspects of Influenza Vaccination among Healthcare Workers. [Review]
    Int J Environ Res Public Health. 2019 10 18; 16(20)Van Hooste WLC, Bekaert M
  • Influenza is a highly contagious airborne disease with a significant morbidity and mortality burden. Seasonal influenza (SI) vaccination has been recommended for healthcare workers (HCWs) for many years. Despite many efforts to encourage HCWs to be immunized against influenza, vaccination uptake remains suboptimal. Sometimes there is a significant sign of improvement, only if numerous measures ar…
  • Factors Associated with the Use of Meditation, U.S. Adults 2017. [Journal Article]
    J Altern Complement Med. 2019 Sep; 25(9):920-927.Macinko J, Upchurch DM
  • CONCLUSIONS: Meditation is one of the most common forms of complementary and alternative medicine in the United States today. While its health benefits are still emerging, public health practitioners and clinicians should be aware of the increasing use of these therapies to treat common health problems, their relatively low prevalence among some groups that might benefit from them (such as older people, those with less healthy lifestyles, and men), and their higher use among those who face barriers to obtaining conventional care.
  • The Essence of Systems Chemistry. [Journal Article]
    Life (Basel). 2019 Jul 11; 9(3)Strazewski P
  • Systems Chemistry investigates the upkeep of specific interactions of an exceptionally broad choice of objects over longer periods of time than the average time of existence of the objects themselves. This maintenance of a dynamic state focuses on conditions where the objects are thermodynamically not very stable and should be rare or virtually inexistent. It does not matter whether they are homo…
  • Optimizing Preanesthesia Care for the Gynecologic Patient. [Review]
    Obstet Gynecol. 2019 08; 134(2):395-408.Dowdy SC, Kalogera E, Scott M
  • In the past, best practices for perioperative management have been based as much on dogma as science. The creation of optimized perioperative pathways, known as enhanced recovery after surgery, has been shown to simultaneously improve patient outcomes and reduce cost. In this article, we critically review interventions (and omission of interventions) that should be considered by every surgical te…
  • Professionalism as the Bedrock of High-Value Care. [Journal Article]
    Acad Med. 2020 Jun; 95(6):864-867.Marcotte LM, Moriates C, … Frankel RM
  • "High-value care" has become a popular mantra and a call to action among health system leaders, policymakers, and educators who are advocating widespread practice changes to reduce costs, minimize overuse, and optimize outcomes in the United States. Regrettably, current research does not demonstrate significant progress in improving high-value care. Many investigators have looked to payment model…
  • Hybrid PET/MRI in major cancers: a scoping review. [Journal Article]
    Eur J Nucl Med Mol Imaging. 2019 Sep; 46(10):2138-2151.Morsing A, Hildebrandt MG, … Høilund-Carlsen PF
  • CONCLUSIONS: The scoping review methodology resulted in the identification of a huge number of records, of which less than 5% were suitable for inclusion and only a limited number allowed conclusions on the advantages/disadvantages of PET/MRI compared to PET/CT in the oncological setting. There was evidence to support the use of FDG PET/MRI in staging of nasopharyngeal cancer and high-risk BC. Preliminary data indicate the superiority of PET/MRI for the detection of local recurrence in PC, local tumour invasion in cervical cancer, and liver metastases in colorectal cancer. These conclusions are based on small datasets and need to be further explored.
  • How do we target the factors that maintain anorexia nervosa? A behaviour change taxonomical analysis. [Journal Article]
    Int Rev Psychiatry. 2019 06; 31(4):403-410.Leonidas C, Nazar BP, … Santos MA
  • All psychological treatments for anorexia nervosa appear to have equal (albeit modest) effects. This may be explained because they target similar processes. Although different psychological treatments have been developed for anorexia nervosa treatment, their taxonomical components have not been compared. This study undertook a taxonomical analysis of behaviour change techniques (BCTs), using the …
  • Challenges and barriers to optimising sedation in intensive care: a qualitative study in eight Scottish intensive care units. [Journal Article]
    BMJ Open. 2019 05 24; 9(5):e024549.Kydonaki K, Hanley J, … Development and Evaluation of Strategies to Improve Sedation practice in inTensive care (DESIST) study investigators
  • CONCLUSIONS: The current implementation of guidelines does not support behaviour change strategies to allow a patient-focused approach to sedation management, which obstructs optimum sedation-analgesia management. Recognition of the various challenges when mandating less sedation needs to be considered and novel sedation-analgesia strategies should allow a system-level approach to improve sedation-analgesia quality.
  • Pure tissue repairs: a timely and critical revival. [Historical Article]
    Hernia. 2019 Jun; 23(3):493-502.Bendavid R, Mainprize M, Iakovlev V
  • "The majority of hernias can be satisfactorily repaired by using the tissues at hand. The use of mesh prosthesis should be restricted to those few hernias in which tension or lack of good fascial structures prevents a secure primary repair. This group includes large direct inguinal hernias and incisional hernias in which the defect is too large to close primarily without undue tension. Most recur…
  • Individualization of FSH Doses in Assisted Reproduction: Facts and Fiction. [Review]
    Front Endocrinol (Lausanne). 2019; 10:181.Broekmans FJ
  • The art of ovarian stimulation for IVF/ICSI treatment using exogenous FSH should be balanced against the relative contribution of other steps of the ART process such as the IVF-lab-phase and the Embryo-Transfer. The aim of ovarian stimulation is to obtain a certain number of oocytes, that will enable the best probability of achieving a live birth. It has been suggested that more oocytes will crea…
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